tco peg3 maleimide

TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Me-Tet-PEG3-Maleimide, an ADC Linker comprising three PEG units, incorporates a Tetrazine group capable of performing a specific inverse electron demand Diels-Alder reaction (iEDDA) with TCO group-containing compounds. Additionally, its maleimide group (-Maleimide) is prone to degradation in aqueous media and has applications in drug delivery studies.