sw-2

SW-2 is an bioactive chemical.

SW209049 是一种硬脂酰辅酶A 9-去饱和酶抑制剂。 SW209049 对H2122细胞表现出有效的活性，IC50为0.13uM。

SW208108 is a tumor-specific irreversible inhibitor of stearoyl CoA desaturase (SCD).

SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg kg, respectively.

SW2_110A 是一种具有细胞渗透性的选择性染色体组 8 染色体域（CBX8 ChD）抑制剂，其 Kd 为 800 nM。在体外，SW2_110A 对 CBX8 ChD 的选择性是所有其他 CBX 对映体的 5 倍。

SW2_110A acetate 是一种选择性的，细胞渗透性的chromobox 同源蛋白CBX8抑制剂（Kd = 800 nM），结合CBX8 N 端色域(ChD)。SW2_110A acetate 对CBX8 N 有很高的亲和力，抑制CBX8与细胞染色质的关联，抑制MLL-AF9诱导的THP1白血病细胞增殖。

SW2_152F 是一种有效的选择性chromobox 2 chromodomain (CBX2 ChD)抑制剂，Kd 为 80 nM。SW2_152F 在体外对 CBX2 ChD 的选择性比其他 CBX paralogs 高 24-1000 倍。

SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mice expressing P301L tau[2].SAR502250 (10-30 mg kg; p.o. once daily for 7 weeks) improves the cognitive deficit in transgenic APP(SW) Tau(VLW) mice after infusion of Aβ25-35[2].SAR502250 (10-30 mg kg; a single p.o.) significantly increases the percentage of lever-presses in the inter-response time (IRT) bin (49-96 s), with a significant augmentation of the percentage of reinforced responses[2].SAR502250 (30 mg kg; i.p. once daily for 28 d) ameliorates chronic stress-induced degradation of the physical state of the mice coat[2].SAR502250 (10-60 mg kg; a single p.o.) decreases hyperactivity produced by psychostimulantsin mice[2]. [1]. Fukunaga K, et, al. 2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; a new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6933-7.[2]. Griebel G, et, al. The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer’s disease in rodents. Sci Rep. 2019 Dec 2;9(1):18045.

2-Hydroxymethyltetrahydropyran is a volatile compound present in the seed oil of Sambucus williamsii (SW), which possesses promising antioxidant activity.

Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 μM, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].