sphinganine 1phosphate

Sphinganine 1-phosphate (鞘氨醇-1-磷酸）是sphingolipid代谢途径中的一个中间产物，结构上和sphingosine相似。D-erythro-Dihydrosphingosine 1-phosphate在小鼠中通过激活S1P1受体对肾脏和肝脏具有保护作用。在智人（Homo sapiens）中作为S1P4的激动剂，并且可能激活GPR63（G蛋白偶联受体），主要用于研究Fabry病，Gaucher病，Krabbe疾病和脑白质营养不良（Leukodystrophy）。

Sphinganine-1-phosphate (d17:0) is a sphingolipid analog of sphinganine-1-phosphate (d18:0) and sphingosine-1-phosphate (d18:1) that has a 17-carbon base. Sphinganine-1-phosphate (d17:0) levels are lower in surgical and cadaver trabecular meshwork samples isolated from patients with primary open angle glaucoma compared with control samples.