10(R)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
gamma-secretasemodulator 2 is a potent and selective γ-secretasemodulator for treatment of Alzheimer's disease .γ-secretasemodulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretasemodulator is usful in particular Alzheimer's disease.
γ-Secretasemodulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM. It is specifically designed for Alzheimer's disease research. Notably, γ-Secretasemodulator 12 exhibits a favorable brain plasma ratio (Kp, brain = 0.72) in mice [1].