pyridomycin

Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg ml).

BDM91514通过抑制AcrB增强antibiotic效能。其在含有8 μg mL吡啶霉素的大肠杆菌BW25113培养条件下显示出生长抑制作用（EC90: 8 μM），且表现出良好的血浆与微粒体稳定性。