primaquine

Primaquine diphosphate 是一种合成的 8-氨基喹啉衍生物，具有抗疟特性。它是一种能破坏间日疟原虫和卵形疟原虫肝脏晚期和潜在组织形态的化合物。

Primaquine 是一种抗疟化合物，也是一种恶性疟原虫配子胞杀灭剂，可清除间日疟原虫的肝内裂殖体和休眠体。

l-Primaquine is used to treat and prevent malaria and to treat Pneumocystis pneumonia.

Primaquine-13C-d3 是 Primaquine 的 13C 和氘代化合物。Primaquine 的 CAS 号为 90-34-6。Primaquine 是一种普遍可用的抗疟疾药物，可防止间日疟疾和卵形疟疾复发，并且是恶性疟疾中有效的杀配子细胞剂。

M 8506 can be used in the treatment of simian malaria and is is less toxic than primaquine in mice.

KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing the earliest stages of the parasites that become either primary hepatic schizonts or hypnozoites (50% inhibitory concentration [IC50] for hypnozoites, KAI407, 0.69 μM, and PQ, 0.84 μM; for developing liver stages, KAI407, 0.64 μM, and PQ, 0.37 μM). KAI407 may represent a new compound class for P. vivax malaria prophylaxis and potentially a radical cure.