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Search Results for " p75ntr "

9

抑制剂 & 化合物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16766	Ro 08-2750
	Ro 08-2750 是一种非肽和可逆的神经生长因子 (NGF) 抑制剂，与 NGF 结合，IC50 约为 1 µM。它是一种选择性 MSI RNA 结合活性抑制剂，IC50 为 2.7 μM。它选择性抑制 NGF 与 p75NTR 的结合，而不是 TRKA。
T11861	LM11A-31 dihydrochloride	Others	Others
	LM11A-31 dihydrochloride 是一种具有高血脑屏障通透性的氨基酸衍生物，能阻断 p75 介导的细胞死亡。它是一种 p75NTR(神经营养蛋白受体 p75) 非肽调节剂，是口服有效的 proNGF 拮抗剂。它可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。
T12384	PD 90780	Others	Others
	PD 90780 是神经生长因子 (NGF) 的非肽拮抗剂。PD 90780 与 NGF 相互作用阻止与 p75NTR 结合。PD 90780 抑制 NGF-p75NTR 相互作用，在 PC12 和 PC12nnr5 细胞中的 IC50 值分别为 23.1 和 1.8 µM
T28206	NSC49652 NSC 49652,NSC-49652	Apoptosis	Apoptosis
	NSC49652 在神经元和黑色素瘤细胞中触发依赖于 p75NTR 和 JNK 活性的凋亡细胞死亡，并抑制黑色素瘤小鼠模型中的肿瘤生长。
TP2278	NTR 368	Others	Others
	cytoplasmic peptide of the neurotrophin receptor p75NTR
T75831	NTR 368 TFA
	NTR 368 TFA, 衍生自p75神经营养蛋白受体(p75NTR)，对应人类受体残基368-381，胶束脂质存在促使其倾向形成螺旋结构。该肽为神经细胞凋亡(apoptosis)的有效诱导剂。
T76813	Bedinvetmab
	Bedinvetmab (ZTS-00508841)为针对神经生长因子(NGF)的犬单克隆抗体(mAb)，通过抑制NGF与肌球蛋白原受体激酶A(trkA)及p75神经营养蛋白受体(p75NTR)的相互作用，应用于犬骨关节炎疼痛的研究。
T35365	LM11A-31 LM11A-31	Others	Others
	LM11A-31 是一种小分子 p75NTR 配体，可逆转中晚期疾病进展的阿尔茨海默病小鼠模型中的胆碱能神经突营养不良。
T74097	THX-B
	THX-B为一高效非多肽类p75NTR（神经营养蛋白受体p75）拮抗剂，适用于糖尿病、肾病、神经退行性及炎症性疾病研究。

化合物

Cat.No: T16766

LM11A-31 dihydrochloride

Cat.No: T11861

Target: Others

Cat.No: T12384

Target: Others

Cat.No: T28206

Synonym: NSC 49652,NSC-49652

Target: Apoptosis

Cat.No: TP2278

Target: Others

Cat.No: T75831

Cat.No: T76813

Cat.No: T35365

Synonym: LM11A-31

Target: Others

Cat.No: T74097

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02614	NGFR/p75NTR Protein, Human, Recombinant (hFc) 神经生长因子,nerve growth factor receptor (TNFR superfamily, membe...	Human	HEK293 Cells
	NGFR/p75NTR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is P08138.
TMPY-02541	NGFR/p75NTR Protein, Mouse, Recombinant (His) Tnfrsf16,神经生长因子,nerve growth factor receptor (TNFR superfami...	Mouse	HEK293 Cells
	NGFR/p75NTR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q9Z0W1.
TMPY-02615	NGFR/p75NTR Protein, Human, Recombinant (His) p75(NTR),TNFRSF16,神经生长因子,p75N...	Human	HEK293 Cells
	NGFR/p75NTR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is P08138.
TMPY-02588	NGFR/p75NTR Protein, Mouse, Recombinant (hFc) p75NGFR,RP23-67E18.6,p75,p75N...	Mouse	HEK293 Cells
	NGFR/p75NTR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is Q9Z0W1.
TMPY-04646	NGFR/p75NTR Protein, Rabbit, Recombinant (His) 神经生长因子,nerve growth factor receptor (TNFR superfamily, membe...	Rabbit	HEK293 Cells
	NGFR/p75NTR Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.8 kDa and the accession number is XP_008269543.1.
TMPY-06973	NGFR/p75NTR Protein, Cynomolgus, Recombinant (His) nerve growth factor receptor (TNFR superfamily, member 16),神...	Cynomolgus	HEK293 Cells
	NGFR/p75NTR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.03 kDa and the accession number is XP_005583674.1.
TMPY-04831	NGFR/p75NTR Protein, Rabbit, Recombinant (hFc) NGFR,nerve growth factor receptor (TNFR superfamily, member ...	Rabbit	HEK293 Cells
	NGFR/p75NTR Protein, Rabbit, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is XP_008269543.1.
TMPY-06959	NGFR/p75NTR Protein, Rat, Recombinant (His) 神经生长因子,nerve growth factor receptor (TNFR superfamily, membe...	Rat	HEK293 Cells
	NGFR/p75NTR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.34 kDa and the accession number is P07174.
TMPJ-01468	pro-Beta NGF Protein, Human, Recombinant β-NGF,NGF,NGFB,Beta-NGF,Beta-Nerve Growth Factor,pro-Beta NG...	Human	E. coli
	The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
TMPH-03222	Rabies virus (RABV) (strain ERA) Glycoprotein (His)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03224	Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03220	Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03221	Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03223	Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His)	RABV	Baculovirus Insect Cells
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03219	Rabies virus (RABV) (strain India) Glycoprotein (His)	RABV	P. pastoris (Yeast)
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPJ-00134	pro-BDNF Protein, Human, Recombinant Brain-Derived Neurotrophic Factor,Abrineurin,BDNF	Human	E. coli
	The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regul...

重组蛋白

NGFR/p75NTR Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02614

Species: Human

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02541

Species: Mouse

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Human, Recombinant (His)

Cat.No: TMPY-02615

Species: Human

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02588

Species: Mouse

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Rabbit, Recombinant (His)

Cat.No: TMPY-04646

Species: Rabbit

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-06973

Species: Cynomolgus

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Rabbit, Recombinant (hFc)

Cat.No: TMPY-04831

Species: Rabbit

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Rat, Recombinant (His)

Cat.No: TMPY-06959

Species: Rat

Expression System: HEK293 Cells

pro-Beta NGF Protein, Human, Recombinant

Cat.No: TMPJ-01468

Species: Human

Expression System: E. coli

Rabies virus (RABV) (strain ERA) Glycoprotein (His)

Cat.No: TMPH-03222

Species: RABV

Expression System: E. coli

Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His)

Cat.No: TMPH-03224

Species: RABV

Expression System: E. coli

Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO)

Cat.No: TMPH-03220

Species: RABV

Expression System: E. coli

Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO)

Cat.No: TMPH-03221

Species: RABV

Expression System: E. coli

Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His)

Cat.No: TMPH-03223

Species: RABV

Expression System: Baculovirus Insect Cells

Rabies virus (RABV) (strain India) Glycoprotein (His)

Cat.No: TMPH-03219

Species: RABV

Expression System: P. pastoris (Yeast)

pro-BDNF Protein, Human, Recombinant

Cat.No: TMPJ-00134

Species: Human

Expression System: E. coli

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