nh2-c2-nh-boc

NH2-C2-NH-Boc (PROTAC Linker 22) 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 分子的合成。

NH2-PEG2-C2-Boc is a polyethylene glycol (PEG)-based PROTAC linker utilized for synthesizing PROTACs[1]. It serves as a non-cleavable 2-unit PEG linker for antibody-drug conjugates (ADCs) in their synthesis[2].

Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based linker utilized for the synthesis of PROTACs. This chemical compound plays a crucial role in connecting the targeted protein and the E3 ubiquitin ligase for selective protein degradation[1].

NH2-PEG5-C2-NH-Boc (PROTAC Linker 17) is a PEG-based compound utilized as a linker in the synthesis of PROTACs[1].

NH2-C2-amido-C2-Boc is an alkyl ether-based PROTAC linker employed in the synthesis of various PROTACs, including the PROTAC CDK2 9 Degrader-1[1]. NH2-C5-NH-Boc can also serve as a suitable precursor for the synthesis of these PROTACs.

Amino-PEG3-t-butyl ester is a PEG derivative containing an amino group with the t-butyl protected carboxyl group. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

JB300 是一种利用PROTAC技术的Aurora A高选择性降解剂（DC50=30 nM），用于肿瘤研究。JB300 由PROTAC靶蛋白配体MK-5108 (pink part)、E3连接酶配体Thalidomide-O-COOH (blue part) 及PROTAC Linker Boc-NH-PEG2-C2-NH2 (black part) 组成，其中E3泛素连接酶配体与Linker的结合物为Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc。

Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc 是一种包含 E3 连接酶配体和连接子的偶联物，结合了基于 Thalidomide 的 CEREBLON 配体和一个 PEG linker。此化合物可以用于合成 PROTAC 降解剂 JB300。

NH2-PEG3-C2-NH-Boc 在生命科学相关研究中具有广泛的应用。