nh-2-peg3

NH2-PEG3 (PROTAC Linker 35) is a polyethylene glycol (PEG) linker utilized in the synthesis of PROTAC (β-NF-JQ1)[1].

NH2-PEG3 hydrochloride is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amino-PEG3-t-butyl ester is a PEG derivative containing an amino group with the t-butyl protected carboxyl group. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

NH2-PEG3-C1-Boc, also known as PROTAC Linker 5, is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

NH2-PEG3-C6-Cl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

NH2-PEG3-VC-PAB-MMAE 是一种 drug-linker conjugate for ADC，结合了可裂解的ADC linker (NH2-PEG3-VC-PAB)与强效微管蛋白抑制剂Monomethylauristatin E (MMAE)，主要用于抗体药物偶联物 (ADC) 的合成。

NH2-PEG3-C2-NH-Boc 在生命科学相关研究中具有广泛的应用。

Boc-NH-PEG3-CH2COOH 是基于 PEG 的 PROTAC linker，用于合成 PROTAC。

Boc-NH-PEG3 (PROTAC Linker 10) 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 的合成分子。

Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是 E3 连接酶配体-linker 偶联物，可用于合成 PROTAC BCL-XL 降解剂 XZ739。

Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a polyethylene glycol (PEG)-based linker compound utilized in the synthesis of PROTACs. This compound serves as a critical component in constructing PROTAC molecules, facilitating the targeted degradation of specific proteins[1].

2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc 是 AUTACPD-L1degrader-3 的 PD-L1 配体-连接子聚合物，并可用于 AUTAC 合成。

Ald-Ph-amido-C2-PEG3-NH-Boc is a polyethylene glycol (PEG)-based bifunctional linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a seven-unit cleavable polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker employed in the synthesis of ADCs[1].

Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized conjugate that functions as an E3 ligase ligand-linker. It includes the cereblon ligand derived from Thalidomide and a linker. This compound, Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc, is employed in the synthesis of PROTAC BET degraders.

PT-129 是一种靶向 G3BP1 2 NTF2 结构域 (蛋白-RNA 相互作用位点) 的 RPOTAC 降解剂，可促进细胞内应激颗粒的分解。该化合物能抑制在应激条件下细胞内应激颗粒的形成，并作用于已存在的应激颗粒，从而干扰 ATF4 的传递，抑制癌细胞增殖。应激颗粒 (SGs) 是在应激条件下形成的无膜细胞质隔室，有助于 ATF4 从成纤维细胞迁移至肿瘤细胞，促进肿瘤生长。G3BP1 2 作为 SGs 网络的中心蛋白，其抑制作用可能降低肿瘤微环境中癌细胞的抗压能力。PT-129 由靶蛋白配体 (red part)G3BP1 2-Targeting ligand-1、E3 连接酶配体 (blue part)Thalidomide 4-fluoride 以及 PROTAC linker (black part)Amino-PEG3-C2-acid 组成；其中 E3 连接酶配体和 linker 构成复合物 Thalidomide-NH-PEG3-propionic acid。