napi-2b

NaPi2b-IN-2（化合物5）为钠依赖性转运蛋白2b（SLC34A2，NaPi2b）的高效抑制剂，对人NaPi2b的IC50为38 nM。该化合物适用于高磷血症研究。

NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. The inhibition of NaPi2b, responsible for intestinal phosphate absorption, is considered to reduce serum phosphate levels, making it a promising therapeutic approach for hyperphosphatemia