napi-2b

lifastuzumAb 是一种人源化的抗 NaPi2b 的 IgG1 类单克隆抗体，常与抗有丝分裂剂单甲基 auristatin E 偶联，通过阻断微管蛋白的聚合来抑制细胞分裂。

NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. The inhibition of NaPi2b, responsible for intestinal phosphate absorption, is considered to reduce serum phosphate levels, making it a promising therapeutic approach for hyperphosphatemia

NaPi2b-IN-2（化合物5）为钠依赖性转运蛋白2b（SLC34A2，NaPi2b）的高效抑制剂，对人NaPi2b的IC50为38 nM。该化合物适用于高磷血症研究。