Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs). Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC50 value of 11.8 μM.
Mammea A BA 对克氏锥虫 (T. cruzi) 显示出有效抗性。通过诱导线粒体功能障碍、产生活性氧 (ROS)、DNA 片段化以及增加酸性液泡数量,Mammea A BA 触发细胞死亡机制,包括细胞凋亡 (apoptosis)、细胞自噬 (autophagy) 和细胞坏死,对于南美锥虫病的研究具有潜在应用价值。