mal-nh-boc

Mal-NH-Boc is a alkyl ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-amido-PEG9-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-C4-NH-Boc is a alkyl ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Mal-N-bis(PEG2-NH-Boc) is a polyethylene glycol (PEG) derived linker specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

N-Mal-N-bis(PEG4-NH-Boc) is a PEG-based PROTAC linker utilized for synthesizing PROTACs[1].

Mal-L-PA-NH-Boc是一种不可降解的ADC linker，用于合成抗体偶联药物（ADCs）。它通过马来酰亚胺基团与抗体上的巯基或氨基反应，从而将药物分子连接到抗体上。这种连接方式有助于提高ADC的稳定性和靶向性，减少药物在非靶组织中的释放。

Mal-PEG4-Lys(t-Boc)-NH-m-PEG24 is a polyethylene glycol (PEG)-based PROTAC linker, suitable for the synthesis of PROTACs[1].

Mal-PEG5-NH-Boc 是一种包括马来酰亚胺基团和 Boc 保护胺基的 PEG 连接体。其亲水性的 PEG 间隔物能够提高其在水溶液中的溶解性。胺在酸性条件下可去除保护。马来酰亚胺基团能够与硫醇基团反应，生成共价键。

Mal-PEG4-NH-Boc 是含有马来酰亚胺基团和Boc保护胺基团的PEG连接体。该亲水性PEG间隔物增强其在水性介质中的溶解度，保护的胺基在酸性条件下可以去保护。马来酰亚胺基团可与硫醇基团反应生成共价键。