lthreoppmp

L-threo-PPMP is an inhibitor of GlcT, which is the UDP-Glc: Ceramide β1,1glucosyltransferase enzyme. It effectively inhibits glycosphingolipid biosynthesis, while also inducing apoptosis. These properties of L-threo-PPMP contribute to its notable anti-cancer activity.

DL-threo-PPMP 作为一种抑制剂,有效地针对疟原虫 (Plasmodium falciparum) 中的鞘氨醇合成酶 (sphingosine synthetase).通过模拟鞘氨醇的底物,DL-threo-PPMP 与该酶结合,进而抑制其活性.这种作用导致宿主细胞内TVM的管状网络被选择性地破坏,并迅速降低了敏感的鞘氨醇合成酶活性,有效阻断疟原虫的繁殖过程.DL-threo-PPMP 常被应用于疟原虫生物学研究及新型抗疟策略的开发.