lenalidomide

Lenalidomide (CC-5013) 是一种免疫调节剂，具有口服活性。Lenalidomide 是泛素 E3 连接酶 cereblon (CRBN) 的配体，可通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解，常用于 PROTAC 产品的合成。

Lenalidomide hemihydrate 是 Thalidomide 的衍生物，也是具有口服活性免疫调节剂，以分子胶的方式作用。它是泛素 E3 连接酶 cereblon 的配体，通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。

Lenalidomide-C4-NH2 hydrochloride is a Cereblon ligand derived from Lenalidomide. It serves as a recruiting agent for the CRBN protein. The compound, known as PROTAC (Compound 24), can be formed by linking Lenalidomide-C4-NH2 hydrochloride to the ligand for the protein. It exhibits inhibitory effects with IC50s of 0.98 nM and 13.7 nM against the growth of RS4;11 and MOLM-13 acute leukemia cell lines, respectively[1].

Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].

Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) serves as a Lenalidomide-based Cereblon ligand that facilitates the recruitment of the CRBN protein. This compound can be connected to the protein's ligand through a linker, resulting in the formation of PROTAC[1].

Lenalidomide-C9-aldehyde is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide-C9-aldehyde can be used in the synthesis of a series of PROTACs, such as INY-03-041. INY-03-041

Lenalidomide-OH 是一种用于 E3 泛素连接酶 (CRBN) 的 cereblon 配体 Lenalidomide 的类似物，用于 CRBN 蛋白的募集。它能够利用 linker 连接到蛋白质配体上形成 PROTAC。

Lenalidomide-PEG3-iodine, an E3 ligase ligand-linker conjugate, consists of a cereblon-based Lenalidomide ligand and a 3-unit polyethylene glycol (PEG) linker. This compound is utilized in creating various proteolysis targeting chimeras (PROTACs), including the highly effective PROTAC BTK degrader SJF620, which has a degradation concentration 50 (DC50) of 7.9 nM[1].

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride is a chemical compound that features a cereblon (CRBN) ligand, functioning as an E3 ubiquitin ligase, along with a linker. It can be utilized to create the PROTAC MD-224[1].

Lenalidomide-propargyl-C2-NH2 hydrochloride is a compound that features a cereblon (CRBN) ligand for the E3 ubiquitin ligase, as well as a linker. It is utilized in the development of the PROTAC MD-224[1] system.

(3S)Lenalidomide-5-Pip-C-Pip-2C-Pip 属于 E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 的类别。该化合物主要用于合成 PROTACCbl-b-IN-1。

(3S)Lenalidomide-5-Br，作为一种E3 泛素酶配体，常被用于合成PROTACCbl-b-IN-1。

Lenalidomide-C13-piperazine-Boc 是一个用于合成PROTAC降解剂NC-R17的E3连接酶配体和连接子偶联物。

Lenalidomide-Pip-butyn 为基于 Lenalidomide 的 E3 连接酶配体-接头结合物 (E3 Ligase Ligand-linker conjugate)，主要用于募集 CRBN 蛋白。该化合物能够连接到蛋白质配体上，进而形成 PROTAC，例如 PROTACSTAT3 降解剂 SD-436。

Lenalidomide-ethyne-C2-Pip-CO-Pip (intermediate 3) 属于E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 类。该化合物主要应用于QA-68 的合成过程中。

(3S)Lenalidomide-piperazine-C-piperidine' 是E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 中的一种。该化合物可用作合成PROTAC ER Degrader-11 的原料。

Lenalidomide-6-F-piperidine-C2-Pip-C-COOH 作为PROTAC BTK Degrader-5的连接子和E3连接酶配体，在恶性淋巴瘤研究中具有应用潜力。

Lenalidomide-F 是 LWY713 的 E3 连接酶配体。LWY713 是一种 PROTAC 类 FLT3 降解剂 (DC50 = 0.64 nM)，通过依赖 cereblon 和蛋白酶体的机制选择性诱导 FLT3 的降解。

Lenalidomide-Glycolic acid 是一种由 E3 连接酶配体和 linker 组成的偶联物，应用于合成 PROTAC-类FLT3降解剂LWY713。

Lenalidomide-hex-5-ynoic acid 是一种E3 连接酶配体和连接子的偶联物，可用于合成PROTAC，如PROTACcGAS degrader-1。

Lenalidomide hydrochloride (CC-5013 hydrochloride) 是 Thalidomide 的衍生物，也是一种具有口服活性免疫调节剂，以分子胶的方式作用。Lenalidomide hydrochloride (CC-5013 hydrochloride) 是一种泛素 E3 连接酶 cereblon (CRBN) 的配体，通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。Lenalidomide hydrochloride (CC-5013 hydrochloride) 特异性抑制成熟 B 细胞淋巴瘤 (包括多发性骨髓瘤) 的生长，并诱导 T 细胞释放白细胞介素-2 (IL-2)。

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG1 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG2 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG3 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.