lat-1-in-1

LAT1-IN-1 (BCH) 是一种 L 型氨基酸转运蛋白 1 (LAT1) 的抑制剂，具有选择性和竞争性。LAT1-IN-1 具有抗肿瘤活性，可以诱导肿瘤细胞凋亡，抑制细胞增殖。

MALAT1-IN-1 是Malat1(转移相关的肺腺癌转录本 1) 的特异性抑制剂。它能够以剂量依赖性方式调节Malat1下游基因，但对Neat1(富核丰富转录本 1) 的表达无影响。

Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。

Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg g corneal tissue hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.