ihch 7041

IHCH7041, also known as (+ -)-IHCH7041, is a DRD2 partial agonist. IHCH7041 contains two enantiomers: (-)-IHCH7041 and (+)-IHCH7041 (optical rotation negative and positive). (+ -)-IHCH7041 has CAS#2813335-29-2. Two isomers have CAS#2813335-07-6 (rotation negative) and 2813335-06-5 (rotation positive), respectively.

(–)-IHCH7041 is a optical rotation negative isomer of IHCH7041. (–)-IHCH7041 is a DRD2 partial agonist. (–)-IHCH7041 showed EC50 = 1.38 nM in Gαi1–γ9 dissociation and 2.75 nM in β-arrestin2 recruitment. (–)-IHCH7041 exhibited a inhibition constant (Ki) of 22.44 nM binding affinity at DRD2. (–)-IHCH7041 has antidepressant properties and reverses cognitive impairment.