hydroquinone

Hydroquinone monobenzoate is an oxidoreductant and potential topoisomerase II inhibitor commercially used in skin whitening treatments and photography development. It may induce DNA damage.

Hydroquinone diacetate (NSC-9277) 是一种 OH• 抑制剂，IC50 为 7.59 μM。

3-hydroxypropanoic acid-pip-hydroquinone-dihydrouracil 是一种由E3连接酶配体和接头结合形成的复合物 (conjugate of E3 ligase ligand and linker),在合成PROTAC HPK1 Degrader-2 的关键步骤中发挥着重要的中间体角色.

Apaziquone (EOquin, EO9) 是一种吲哚喹诺酮类化合物，作为生物还原型前药，与较早的化疗化合物丝裂霉素C具有化学类似性。

2,5-Di-tert-butylhydroquinone (BHQ) 是一种有效和选择性的内质网 Ca2+-ATPase 抑制剂，可调节5-LO 以及COX-2活性，IC50分别为 1.8 和 14.1 μM。

Thymohydroquinone (Thymoquinol) 是中药材百里香、牛至和其他唇形科植物中含有的单萜酚类化合物。 Thymohydroquinone 抑制癌细胞生长、减少氧化应激和调节炎症反应，在无细胞实验中清除2,2-二苯基-1-picrylhydrazyl 自由基(IC50 = 2.4 μg ml)，在浓度为1.6至6.4 μg ml 的氧自由基吸收能力(ORAC)实验中，它的Trolox 当量值为2.6胸腺对苯二酚对A2780、OVCAR-8和CIS-A2780卵巢癌细胞(IC50分别为3.1、8.9和9.8 μM)和人卵巢永生化上皮细胞(IC50 = 14 μM)的生长有抑制作用，体外对恶性疟原虫也有抑制作用(IC50 = 15.9 μM)。

Tetrachlorohydroquinone dimethyl ether 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T123888。

2-Prenylhydroquinone-1-glucoside 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131092。

2-Methoxyhydroquinone 是一种酚类化合物，能够抑制 TNF-α 引发的趋化因子 (C-C 基序) 配体 2 (CCL2) 的生成，其IC50值为 64.3 µM。同时，2-Methoxyhydroquinone 也是 Hsp90 抑制剂 Geldanamycin 的合成前体。

Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes. In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.

2,6-Dimethylhydroquinone is an endogenous metabolite.

Trimethylhydroquinone 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65486，CAS号为 700-13-0。

Colutehydroquinone 是一种从Colutea arborescens 的根皮中提取的异黄酮，具有抗真菌活性。

2,5-Dihydroxybenzoic acid (Gentisic acid) 是一种苯甲酸的代谢物，也是一种纤维母细胞生长因子(fibroblast growth factor)的强效抑制剂。

2,5-Dihydroxyacetophenone (Quinacetophenone) 是从熟地黄中分离出的一种天然产物，通过阻断 ERK1 2和 NF-κB 信号通路，抑制活化巨噬细胞中炎症介质的产生。

Arbutin (p-Arbutin) 是一种从熊果植物 Arctostaphylos uvaursi 中分离出的天然多酚，具有抗氧化，抗炎和抗肿瘤特性。它是一种脱色剂，也是一种黑色素细胞中酪氨酸酶的竞争性抑制剂，对单酚酶的 Kiapp 值为 1.42 mM；对二酚酶Kiapp 的值为 0.9 mM。

Mequinol (Leucobasal) 是一种Mercurialis spp 的生物活性成分，常用于皮肤褪色。

HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)) 是一种强力的亲脂性酚类抗氧化剂。它通过与活性氧直接反应，清除 ROS，从而形成更稳定的自由基，具有很强的抗氧化活性。

Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 300 nM). Early in vitro studies showed that ansatrienin B potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. Ansatrienin B is a hydroquinone form of ansatrienin A .

Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Collagen-IN-1 effectively reduces the expression of P-selectin, activation of glycoprotein IIb IIIa, and release of adenosine triphosphate and CD63 from platelets. This compound holds promise for research into platelet-related thrombosis diseases [1].

Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerated and more effective at inhibiting tumor growth compared with mitoxantrone in a human xenograft tumor regression mouse model. Mechanistically, we found that ethonafide inhibited topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIalpha and -beta. In addition, ethonafide induced a potent G(2) cell cycle arrest in the DU 145 human prostate cancer cell line. By creating stable cell lines with decreased expression of topoisomerase IIalpha or -be......

Tetrahydroauroglaucin，一种对苯二酚的成员，表现出抗氧化活性。

(+ -)-1,2-Propylene-d6 Oxide (Stabilized with hydroquinone) 是 (+ -)-1,2-Propylene Oxide 的氘代化合物。(+ -)-1,2-Propylene Oxide 的 CAS 号为 75-56-9。