hcb1r

Taranabant (MK-0364) 是一种具有选择性和高效性的 cannabinoid 1 (CB1) 受体反向激动剂，可用于研究肥胖和尼古丁依赖。

GAT564 (Compound 15d) is a highly effective allosteric modulator of cannabinoid 1 receptor (CB1R), having EC50 values of 87 nM and 320 nM for cAMP and β-arrestin2, respectively. It significantly enhances the binding of orthosteric ligands to hCB1R. Moreover, GAT564 exhibits remarkable efficacy as a topical agent, resulting in a significant reduction of intraocular pressure (IOP) in an ocular normotensive murine model of glaucoma [1].

CBR Agonist-2 是一种 CB1 激动剂 (EC50: 960 nM)(Ki: 970 nM)(CB1R; CB1 配体)。CBR Agonist-2 是一种很有前景的工具，能够用于 hCB1R 参与的内源性大麻素系统相关疾病的研究。