epimer

MS83epimer 1 是 MS83 的 epimer。MS83 是一种概念验证型 PROTAC，由 KEAP1 配体与 BRD4/3/2 结合剂结合而成的产物。

Negative control for LC 2.

Tacrolimus anhydrous 8-epimer is a new l-pipecolic acid macrolide lactone, an important immunosuppressive drug that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.

3 Hydroxy Midostaurin Epimer 1-d5 是 3 Hydroxy Midostaurin Epimer 1 的氘代化合物。3 Hydroxy Midostaurin Epimer 1 的 CAS 号为 945260-14-0。

3 Hydroxy Midostaurin Epimer 2-d5 是 3 Hydroxy Midostaurin Epimer 2 的氘代化合物。3 Hydroxy Midostaurin Epimer 2 的 CAS 号为 155848-20-7。

Lauroyl-CoA, epimer (Lauroyl-coenzyme A epimer) 是辅酶 A 的一种衍生物。

(-)-Gallocatechin ((−)-GC) 是一种 (-)-Epigallocatechin (EGC) 的差向异构体，常存在于各种茶产品中，具有抗氧化特性。

WIN 5063-3 is the enantiomeric analog of the antimicrobial Thiamphenicol.

Aldose 1-epimerase (mutarotases) 是关键碳水化合物代谢酶，主要催化己糖如葡萄糖及半乳糖的α-与β-端基异构体互转。对于碳水化合物代谢及复杂寡糖生成至关重要。

NMP-ACA (Cefepime impurity)是一种 Cefepime 的杂质，可用于生命科学领域相关实验。

D-Galactose 是一种天然己糖，是葡萄糖的C-4差向异构体，可与葡萄糖结合形成乳糖，常用于构建动物衰老模型。

16α-Hydroxyprednisolone 是糖皮质激素布地奈德 22(R) epimer 构型的代谢物，经过 CYP3A 酶代谢生成。

(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.

DTE (Dithioerythritol)是一种含硫的糖衍生物，来源于四碳单糖赤藓糖，是 dithiothreitol（DTT）的差向异构体。DTE 常作为还原剂用于生物化学和分子生物学实验中，以维持巯基处于还原状态、稳定蛋白质结构，并支持氧化还原敏感的酶学和结构研究。

3-epi-25-hydroxy Vitamin D3is the C-3 epimer of 25-hydroxy vitamin D3.1Dietary administration of 3-epi-25-hydroxy vitamin D3(0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. 1.Djekic-Ivankovic, M., Lavery, P., Agellon, S., et al.The C-3α epimer of 25-hydroxycholecalciferol from endogenous and exogenous sources supports normal growth and bone mineral density in weanling ratsJ. Nutr.147(2)141-151(2017)

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).[3] 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.[3] In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. Analytical and biological comparisons of synthetic 17(R)-RvD1 with endogenously derived 17(R)-RvD1 have confirmed its identity as matching the natural product.[4]

17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when used at concentrations ranging from 0.1 to 10 nM. 17(R)-Protectin D1 (0.01-10 ng) reduces the recruitment of neutrophils in a mouse model of TNF-α-induced peritonitis. 1.Serhan, C.N., Fredman, G., Yang, R., et al.Novel proresolving aspirin-triggered DHA pathwayChem. Biol.18(18)976-987(2011)

11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.2 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.[3] .

15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.

Chlortetracycline is an analog of tetracycline , a broad spectrum antibiotic. In addition to its actions against microorganisms, chlortetracycline suppresses inflammation by inhibiting neutrophil action and other aspects of the innate immune response. 4-epi-Chlortetracycline is an epimer of chlortetracycline.

7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1 , which contains a 7(R) hydroxyl group. It can be used as an experimental negative control.

5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes. It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore. 5(S),12(S)-DiHETE is an epimer of leukotriene B4 that is weakly chemotactic for PMNL.

Epitetracycline is an epimer of the antibiotic tetracycline . Epimers of tetracycline form without catalysis and are considered degradation products. Epitetracycline has decreased activity as an antibiotic or a Tet repressor effector but may have stronger toxic effects in animals.

D-chiro-Inositol (D-(+)-CHIRO-INOSITOL) 是肌醇差向异构体，存在于某些哺乳动物糖基磷脂酰肌醇蛋白锚和具有胰岛素样生物特性的肌醇磷脂聚糖中。它能够抑制高血糖，改善胰岛素抵抗。它用于多囊卵巢综合征和糖尿病的相关研究。