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Targets Recommended: Others

22

抑制剂 & 化合物

1

天然产物

1

化合物库

5

重组蛋白

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Cat. No. Product Name
L2191 抗乳腺癌化合物库

1939 compounds
1939 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究;

化合物库

抗乳腺癌化合物库
Cat.No: L2191
Compounds: 1939
Cat. No. Product Name Target Signaling Pathways
T6793 BRD7552

Others Others
BRD7552 是PDX1转录因子诱导剂,它能够上调人类原代胰岛和导管细胞中 PDX1 的表达,诱导 PDX1 启动子的表观遗传变化与转录激活一致,提高胰岛素表达。其中 PDX1 是参与胰腺发育和β细胞功能的关键转录因子。
T4367 Mycro 3

Mycro-3

c-Myc; Autophagy Autophagy; Cell Cycle/Checkpoint
Mycro 3 在全细胞分析中对 c-Myc 具有强效选择性,可用于胰腺癌的研究。
T8766 GOT1 inhibitor-1

GOT1 inhibitor 2c

Others Others
GOT1 inhibitor-1 (GOT1 inhibitor 2c) 是一种新型的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂(IC50:8.2 uM),是一种戊酸衍生物。 它可用于以及胰腺导管腺癌 (PDAC) 。
T2613 Almorexant

阿莫伦特,ACT 078573

OX Receptor GPCR/G Protein; Neuroscience
Almorexant (ACT 078573) 是一种有效的竞争性食欲素 1 受体 (OX1)/食欲素 2 受体 (OX2) 双重拮抗剂,OX1 和 OX2 的 Ki 值分别为 1.3 和 0.17 nM。
T6155 Almorexant hydrochloride

ACT-078573 hydrochloride,Almorexant HCl

OX Receptor GPCR/G Protein; Neuroscience
Almorexant hydrochloride (ACT-078573 hydrochloride) 是一种有效的竞争性食欲素 1 受体(OX1)/食欲素 2 受体 (OX2) 双重拮抗剂,OX1 和 OX2 的 Ki 值分别为 1.3 和 0.17 nM。
T77522 BCAT-IN-4

Others Others
BCAT-IN-4 是一种具有有效性的 BCAT 抑制剂 对 hBCATc 的 IC50 值为 2.35 μM。 BCAT-IN-4 具有抗癌活性,可用于研究胰腺导管腺癌。
T76873 Nidanilimab

CAN04

IL Receptor Immunology/Inflammation
Nidanilimab (CAN04) 是一种完全人源化的 IL1RAP 单克隆抗体,其 Kd 值为 1.10 pM。Nidanilimab 具有抗肿瘤活性,切断 IL1α 和 IL1β 信号通路,并诱导免疫系统破坏肿瘤细胞。Nidanilimab 可用于研究非小细胞肺癌 (NSCLC) 和胰腺导管腺癌 (PDAC) 等实体癌。
T60202 MMRi62

7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

Ferroptosis Apoptosis
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol) 是一种铁死亡 (ferroptosis) 诱导剂,靶向 MDM2-MDM4 (抑癌基因 p53 负调控因子)。MMRi62 对胰腺导管腺癌 (PDAC) 细胞显示出 p53 独立的促凋亡 (apoptosis) 活性,并诱导其自噬 (autophagy)。MMRi62 诱导铁死亡,伴随着活性氧增加和铁蛋白重链 (FTH1) 溶酶体降解。MMRi62 还可导致突变型 p53 的蛋白酶体降解,并对具有 KRAS 和 TP53 高频突变特征的原位异种移植 PDAC 小鼠模型具有体内药效。
T69106 Avarol

Others Others
Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheimer's disease.
T24693 QD325

QD 325,QD-325

Others Others
QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in the nucleus, endoplasmic reticulum, and mitochondria of pancreatic ca
T70646 Deltarasin HCl

Others Others
Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor. Deltarasin can inhibit KRAS-PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/RAF signaling in human pancreatic ductal adenocarcinoma cell lines. The anti-cancer cell activity of deltarasin can be enhanced by simultaneously blocking tumor protective" autophagy
T62748 Nampt-IN-9

Others Others
Nampt-IN-9 (Compound 8) 是一种有效的 NAMPT 抑制剂,具有抗癌作用。Nampt-IN-9 能够用于研究胰腺导管腺癌。
TP1048 Secretin, porcine

Porcine secretin acetate

Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid. Secretin porcine stimulates pancreatic and gastric secretions to a
TP1047 Secretin, porcine TFA (17034-34-3 free base)

Porcine secretin TFA,Secretin, porcine TFA

Secretin, porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.Secretin porcine stimulates pancreatic and gastric secretions to ai
T75973 Secretin, porcine TFA

Porcine secretin TFA (Porcine secretin TFA) 是一种含有27个氨基酸的多肽,能够影响胰腺腺泡细胞和导管上皮细胞,促进碳酸氢盐丰富的流体生成。
T70223 UA8967

Others Others
UA8967 is a membrane-active anti-tumor agent. Cytotoxicity studies in six pancreatic cancer cell lines, one normal human pancreatic ductal epithelial line and two colon cancer cells showed the IC50s UA8967 ranged from 12–61 μM for exposure times of 72 h. There was also no selective inhibition of DNA, RNA or protein synthesis after exposure to UA8967. UA8967 is observed to affect the plasma membrane.
T79689 SIRT6-IN-3

Sirtuin Chromatin/Epigenetic; DNA Damage/DNA Repair
SIRT6-IN-3 (compound 8a) 作为SIRT6的选择性抑制剂,其IC50值为7.49 μM。该化合物能有效抑制胰腺导管腺癌 (PDAC) 细胞的增殖,并诱导细胞凋亡。SIRT6-IN-3 通过抑制 DNA 损伤的修复作用,增强了吉西他滨对癌细胞的敏感性,常用于胰腺癌相关研究。
T72355 KRAS G12D inhibitor 16

Others Others
KRAS G12D inhibitor 16 是一种 KRAS G12D 抑制剂。KRAS G12D inhibitor 16 对 KRAS G12D 和 KRAS G12D 突变具有抑制活性,IC50值分别为 0.7 nM 和 0.35 μM。KRAS G12D inhibitor 16 可用于多种恶性肿瘤的研究,如胰腺导管腺癌(PDAC)、结肠直肠癌(CRC)、非小细胞肺癌(NSCLC)。
T82673 CPF-7

Caerulein precursor fragment

CPF-7(Caerulein precursor fragment)是一种促进胰岛素释放的肽,可以通过增加PANC-1导管细胞中Snai1表达来引导上皮-间质转换(EMT),并且CPF-7还能通过提高Ngn3表达以诱导外分泌细胞可塑性。此外,CPF-7适用于2型糖尿病的相关研究。
T83880 C18 Ceramide-1-phosphate (d18:1/18:0) ammonium

Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate

Others Others
C18 Ceramide-1-phosphate (d18:1/18:0) 是一种在鼠皮肤中发现的长链ceramide-1-phosphate。它能在0.5至5 µM的浓度范围内促进分离的小鼠骨髓来源的多能间充质细胞和人脐静脉内皮细胞(HUVECs)的迁移。与胰腺癌干细胞相比,CFPAC-1胰管腺癌细胞中C18 Ceramide-1-phosphate (d18:1/18:0)的水平有所增加。在Langendorff分离的灌流小鼠心脏的离体缺血模型中,心肌中C18 ceramide-1-phosphate (d18:1/18:0)的水平有所增加。
T63902 XP-524

Others Others
XP-524 是 BET 和 EP300 的有效抑制剂。 XP-524 在体内具有显著的杀肿瘤作用,能够阻止 KRAS 诱导的体内肿瘤转化,并延长两种侵袭性 PDAC 转基因小鼠模型的存活时间。XP-524 也提高了自身肽的表达及将肿瘤细胞向细胞毒性 T 淋巴细胞的募集。XP-524 对胰腺导管腺癌(PDAC)表现出研究潜力。
T36103 TW9

TW9

Others Others
TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μM) and for HDAC1 over HDAC2 (IC50= 2.5 μM). TW9 (50 nM) induces apoptosis in, and inhibits proliferation of, MIA PaCa-2 pancreatic cancer cells. It induces cell cycle arrest at the G1phase in HPAC pancreatic cancer cells when used at a concentration of 2 μM. TW9 acts synergistica...

化合物

BRD7552
Cat.No: T6793
Synonym:
Target: Others
Mycro 3
Cat.No: T4367
Synonym: Mycro-3
Target: c-Myc, Autophagy
GOT1 inhibitor-1
Cat.No: T8766
Synonym: GOT1 inhibitor 2c
Target: Others
Almorexant
Cat.No: T2613
Synonym: 阿莫伦特,ACT 078573
Target: OX Receptor
Almorexant hydrochloride
Cat.No: T6155
Synonym: ACT-078573 hydrochloride,Almorexant HCl
Target: OX Receptor
BCAT-IN-4
Cat.No: T77522
Synonym:
Target: Others
Nidanilimab
Cat.No: T76873
Synonym: CAN04
Target: IL Receptor
MMRi62
Cat.No: T60202
Synonym: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol
Target: Ferroptosis
Avarol
Cat.No: T69106
Synonym:
Target: Others
QD325
Cat.No: T24693
Synonym: QD 325,QD-325
Target: Others
Deltarasin HCl
Cat.No: T70646
Synonym:
Target: Others
Nampt-IN-9
Cat.No: T62748
Synonym:
Target: Others
Secretin, porcine
Cat.No: TP1048
Synonym: Porcine secretin acetate
Target:
Secretin, porcine TFA (17034-34-3 free base)
Cat.No: TP1047
Synonym: Porcine secretin TFA,Secretin, porcine TFA
Target:
Secretin, porcine TFA
Cat.No: T75973
Synonym:
Target:
UA8967
Cat.No: T70223
Synonym:
Target: Others
SIRT6-IN-3
Cat.No: T79689
Synonym:
Target: Sirtuin
KRAS G12D inhibitor 16
Cat.No: T72355
Synonym:
Target: Others
CPF-7
Cat.No: T82673
Synonym: Caerulein precursor fragment
Target:
C18 Ceramide-1-phosphate (d18:1/18:0) ammonium
Cat.No: T83880
Synonym: Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate
Target: Others
XP-524
Cat.No: T63902
Synonym:
Target: Others
TW9
Cat.No: T36103
Synonym: TW9
Target: Others
Cat. No. Product Name Target Signaling Pathways
T36179 Aspulvinone O

Others Others
Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) redu...

天然产物

Aspulvinone O
Cat.No: T36179
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPK-00721 CX3CL1/Fractalkine Protein, Mouse, Recombinant (His & Avi), Biotinylated

Neurotactin,CXC3C,ABCD-3,Fkn,Fractalkine,NTT,Cx3cl1,SCYD1,Cx...

Mouse HEK293 Cells
Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as pancreatic ductal adenocarcinoma.
TMPY-01346 Psoriasin/S100A7 Protein, Human, Recombinant

S100 calcium binding protein A7,PSOR1,S100A7c

Human E. coli
Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role...
TMPY-00585 Annexin A8 Protein, Human, Recombinant (His)

ANX8,annexin A8

Human E. coli
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-proliferative isolated pubertal mouse mammary ductal epithelium and after enforced involution, but not in isolated highly proliferative terminal end buds (TEB) or during pregnancy. ANXA8 as a potential mediator of quiescence in the normal mouse mammary ...
TMPY-02497 S100A15 Protein, Mouse, Recombinant (His & MBP)

S100a17l1,Gm1020,S100a15a,AY465109,S100A7f,S100A7L1,S100 cal...

Mouse E. coli
Koebnerisin is also known as protein S100-A7A (S100A7A), S100 calcium-binding protein A7-like 1 (S100A7L1) or S100 calcium-binding protein A15 (S100A15). Human S100A7A / S100A15 is a novel member of the S100 family of EF-hand calcium-binding proteins and was recently identified in psoriasis, where it is significantly upregulated in lesional skin. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesti...
TMPY-04075 CLIC1 Protein, Human, Recombinant (His)

NCC27,G6,chloride intracellular channel 1

Human E. coli
Members of the CLIC family are largely soluble proteins that possess the intriguing property of spontaneous insertion into phospholipid bilayers to form integral membrane ion channels. Chloride intracellular channel 1 (CLIC1), a newly discovered member of the chloride channel protein family, has been implicated in multiple human cancers. CLIC1 is a Chloride Intracellular Ion Channel protein that exists either in a soluble state in the cytoplasm or as a membrane bound protein. CLIC1 acts as a put...

重组蛋白

CX3CL1/Fractalkine Protein, Mouse, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00721
Species: Mouse
Expression System: HEK293 Cells
Psoriasin/S100A7 Protein, Human, Recombinant
Cat.No: TMPY-01346
Species: Human
Expression System: E. coli
Annexin A8 Protein, Human, Recombinant (His)
Cat.No: TMPY-00585
Species: Human
Expression System: E. coli
S100A15 Protein, Mouse, Recombinant (His & MBP)
Cat.No: TMPY-02497
Species: Mouse
Expression System: E. coli
CLIC1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04075
Species: Human
Expression System: E. coli
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