dd 4

Add 4743 is an analog of sitoglitazone, which is also a fat-forming agent.

alphaSYN-IN-NAB2 是一种神经元保护剂，是一种由 NAB2基因编码的蛋白质。NAB2 高效且具有选择性地保护多种细胞免受 α-syn 毒性。NAB2 对依赖于 E3 泛素连接酶 Rsp5/Nedd4 的内体转运具有促进作用。NAB2 确定 α-syn 生物学中的一个可活性分子节点，该节点可以纠正其潜在病理学的多个方面，包括功能失调的内体和内质网到高尔基体囊泡的运输。NAB2参与细胞分化、凋亡和应激反应等细胞过程，可用来研究癌症、神经发育和神经元活动。

MKK7-COV-9 是一种具有选择性和有效性的 MKK7 共价抑制剂，对 MKK7 引导的蛋白-蛋白相互作用有抑制作用。MKK7-COV-9 中断原代 B 细胞应对 LPS 的激活。MKK7-COV-9 在高浓度下显示出较低的细胞毒性。

Delamanid D4 is deuterium-labeled Delamanid. Delamanid is a newer mycobacterial cell wall synthesis inhibitor that inhibits the synthesis of mucus acid.

Pimethixene (Calmixen) 是抗组胺和抗血清素剂，用作抗偏头疼剂。它是高效多靶点拮抗剂。

Pimethixene maleate (Pimetixene maleate) 是一种高效的 5-HT2B 受体拮抗剂，具有镇静和镇咳活性。Pimethixene maleate 抑制 5-HT1A，5-HT2A，5-HT2B，5-HT2C，组胺 H1，多巴胺 D2 和 D4.4 以及毒蕈碱 M1 和 M2，可用于研究儿童干咳和刺激性咳嗽。

BIX-01294 trihydrochloride 是可逆且高度选择性的G9a 和GLP 组蛋白甲基转移酶抑制剂，IC50分别为 1.9 μM 和 0.7 μM。它可诱导坏死性凋亡和自噬，具有抗肿瘤活性。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP。

DDD489 作为一种选择性隐孢子虫赖氨酸 tRNA 合成酶 (CpKRS) 抑制剂，表现出卓越的效力，其 IC50 值达到 0.85 uM。该化合物在体内外研究中均展示了对隐孢子虫的有效抗性。

4-Hydroxybenzoicacid-d4是4-Hydroxybenzoicacid的氘代物，4-Hydroxybenzoicacid为苯甲酸的酚类衍生物，能够抑制大多数革兰氏阳性菌及部分革兰氏阴性菌的生长 (IC50: 160 μg/mL)。

DTP3 是一种选择性 MKK7/GADD45β 抑制剂，靶向 NF-κB 通路，可抑制癌症。

Heclin 是一种 HECT E3 泛素连接酶抑制剂，通过抑制 Smurf2、Nedd4 和 WWP1 起作用，IC50 值分别为 6.8、6.3 和 6.9 μM。

1-Benzyl-I3C 是一种抗癌、抗增殖、抗雄激素的神经前体细胞表达发育性下调蛋白4-1(NEDD4-1)抑制剂，能够直接抑制 NEDD4-1 的泛素化活性和人黑色素瘤细胞和乳腺癌细胞等癌细胞增殖，具有高效的优点（IC50＝12.3 μM）。

Dexelvucitabine (RVT) 是一种胞苷类似物，一种口服有活性的核苷逆转录酶抑制剂。它是一种 2'-脱氧胞苷抗逆转录病毒剂。它是一种有效的抗 HIV-1病毒剂，这些病毒聚合酶中含有胸苷类似物和/或 M184V 突变。

SP 600125, negative control 是 SP 600125 的甲基化类似物，可用作SP 600125的阴性对照，对 DTP3和GADD45β/MKK7（生长停滞和 DNA 损伤诱导型 β/介原活化蛋白激酶激酶 7）具有抑制作用，能够恢复活化。SP 600125, negative control 对 JNK2 和 JNK3 的 IC50s 分别为 18 和 24 μM。

Zunsemetinib (ATI-450) 是一种具有口服活性和选择性的 p38α 丝裂原激活蛋白激酶激活蛋白激酶2 (MK2)通路抑制剂。Zunsemetinib 可用于研究脊柱关节炎和类风湿性关节炎。

ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2.

Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 µM, respectively. Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and the large-conductance calcium-activated potassium channel (KCa1.1). It also inhibits various ion channels, including TRPC3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice ......

Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate. It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 µg/L. Clofibric acid has been found in wastewater effluent.

Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin resistance induced by hydrogen peroxide. Gliclazide (5 and 10 μg/ml) reduces LDL oxidation by human aortic smooth muscle cells (HASMCs), decreasing TBARS content and 8-isoprostane levels. It also decreases oxidized LDL-induced HASMC proliferation and monocyte adhesion when used at concentrations ranging from 1 to 10 μg/ml. Gliclazide (5 mg/kg) reduces serum glucose levels and increases glucose uptake by isolated rat hindquarters in a model of diabetes induced by streptozotocin (STZ).

BIX-01294 是高度选择性的G9a 和GLP 组蛋白甲基转移酶可逆抑制剂。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP，可诱导坏死性凋亡和自噬，具有抗肿瘤活性。

Vitamin B3-d4 (Nicotinic acid-(ring-d4)) 是 Niacin 的氘代物，可用于跟踪 Niacin 在体内的代谢。

Taurocholic Acid-d4 Sodium是Taurocholic Acid的氘代标记化合物，可用于同位素示踪。Taurocholic Acid是一种具有免疫调节作用的胆汁酸，对肠道和肝脏中脂肪和固醇的消化和吸收起着至关重要的作用。

2-Quinoxalinecarboxylic acid-d4 是 2-Quinoxalinecarboxylic acid 的氘代化合物。2-Quinoxalinecarboxylic acid 的 CAS 号为 879-65-2。

Glycocholic acid-d4 是 Glycocholic acid 的氘代化合物。Glycocholic acid 的 CAS 号为 475-31-0。Glycocholic acid 是一种胆汁酸，具有抗肿瘤活性，能够靶向作用于耐药泵和非耐药泵通路。