concanavalin a

Concanavalin A 属于天然产物，是一种植物凝集素 (糖类结合蛋白)。Concanavalin A 具有抗肿瘤活性，还可诱导急性肝损伤。

A-770041 是具有口服活性和选择性的 Lck 抑制剂，抑制伴刀豆球蛋白 A 刺激的 IL-2 在全血中的产生，可防止心脏同种异体移植物排斥反应。A-770041 通过抑制调节性 T 细胞中 TGF-β 的产生来减轻肺纤维化。

Concanavalin A (Fluorescein)是一种可用于生命科学研究的重要生物材料或有机化合物。

Concanavalin A (Con A) Rhodamine作为一种植物源性凝集素，它能与多糖、多肽等生物分子产生特异性相互作用，进而被用作生物分析中的探针工具。Concanavalin A (Con A) Rhodamine也是一种在生命科学研究中可作为生物材料或有机化合物使用的物质。

Concanavalin A (agarose) 由Concanavalin A 与琼脂糖偶联而成。Concanavalin A 是一种从刀豆 (Canavalia ensiformis) 中提取的四聚体金属蛋白凝集素。Concanavalin A (agarose) 能结合含有 α-D-吡喃甘露糖基、α-D-吡喃葡萄糖基及其空间相关残基的分子，用于纯化糖蛋白、多糖和糖脂。此外，Concanavalin A (agarose) 还用于酶抗体缀合物的纯化、IgM 的纯化与膜囊泡的分离等领域。

Rupatadine(UR-12592,卢帕他定)是一种有效和可口服的PAF和组胺H1受体的双重拮抗剂，Ki 值分别为 0.55 μM 和 0.1 μM，能够缓解过敏症状并抗炎，可用于过敏性鼻炎和慢性荨麻疹。

PQA-18 是p21激活激酶2（PAK2；IC50 = 10 nM）的有效抑制剂，并作为Ppc-1（产品编号42352）衍生物展现出免疫抑制特性。该化合物能够降低由刀豆A（产品编号14951）刺激的Jurkat T细胞中IL-2的生成（IC50 = 400 nM）。在应用0.1% PQA-18的情况下，NC Nga小鼠模型显示异位性皮炎的严重程度、血清IgE水平及皮肤厚度有所减轻。此外，0.05%的剂量可有效减少该小鼠模型中皮肤神经纤维的密度。PQA-18（4 mg kg）还在大鼠小肠移植模型中显著提高了移植物的存活率。

cGAS-IN-4 (Compound 36) 是一种口服有效的环状 GMP-AMP 合酶 (cGAS) 抑制剂，对 h-cGAS 和 m-cGAS 的 IC50 分别为 32 nM 和 5.8 nM。在 THP-1 cell 细胞中，cGAS-IN-4 以 IC50 为 60 nM 抑制 cGAMP，从而提高细胞效能。在小鼠模型中，该化合物对 Concanavalin A 诱发的急性肝损伤展现抗炎作用。

Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg ml for the rat liver enzyme).2Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50= 10 μg ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner. 1.Xu, Z., Schenk, A., and Hertweck, C.Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybridsJ. Am. Chem. Soc.129(18)6022-6030(2007) 2.Aoyama, T., Kojima, F., Yamazaki, T., et al.Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activitiesJ. Antibiot. (Tokyo)46(5)712-718(1993)

Ferrichrome (iron-free) 是一种异羟肟酸盐铁载体，可由各种真菌产生（包括 U. sphaerogena），促进这些生物体对铁的螯合和吸收，还被细菌用作异源铁载体，包括铜绿假单胞菌和副溶血性弧菌。 Ferrichrome (iron-free) (0.8 μM) 可以抑制由刀豆球蛋白 A 诱导的小鼠脾脏单核细胞增殖，并减少刀豆球蛋白 A 刺激的 CD4+ T 细胞的数量。它还以浓度依赖性方式抑制过氧化氢对 LDL 的血红素催化氧化。

Sydowinin B is a xanthone polyketide that has been found inA. sydowiiand has immunosuppressant activity.1It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20.8 μg ml, respectively).2Sydowinin B inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by cytochalasin B and N-Formyl-Met-Leu-Phe with IC50values of 21.2 and 12.62 μM, respectively.3

Colletodiol is a fungal metabolite that has been found inD. grovesiiand has immunosuppressant and antiviral activities.1,2It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC50s = 12 and 5 μg ml, respectively).1Colletodiol inhibits influenza A viral replication in HeLa-IAV-Luc cells.2 1.Fujimoto, H., Nagano, J., Yamaguchi, K., et al.Immunosuppressive components from an ascomycete, Diplogelasinospora grovesiChem. Pharm. Bull.46(3)423-429(1998) 2.Lai, W., Wang, S., and Ye, X.Colletodiol inhibits the replication of influenza A virus WSN H1N1 by reducing the activity of viral RNA polymeraseWei Sheng Wu Xue Bao53(12)1334-1339(2013)

Remisporine B is a polyketide and derivative of remisporine A that has been found inPenicilliumand has immunosuppressant activity.1,2It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 30.1 and 32.4 μg/ml, respectively).1 1.Liu, H., Chen, S., Liu, W., et al.Polyketides with immunosuppressive activities from mangrove endophytic fungus Penicillium sp. ZJ-SY2Mar. Drugs14(12)217(2016) 2.Kong, F., and Carter, G.T.Remisporine B, a novel dimeric chromenone derived from spontaneous Diels-Alder reaction of remisporine ATetrahedron Lett.44(15)3119-3122(2003)

(-)-Rasfonin is a fungal metabolite that has been found in T. terrophilus.1 It inhibits proliferation of mouse splenocytes induced by concanavalin A and LPS (IC50s = 0.7 and 0.5 μg ml, respectively). References1. Fujimoto, H., Okamoto, Y., Sone, E., et al. Eleven new 2-pyrones from a fungi imperfecti, Trichurus terrophilus, found in a screening study guided by immunomodulatory activity. Chem. Pharm. Bull. (Tokyo) 53(8), 923-929 (2005).

Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells.

Plipastatin A1是一种在B. cereus中发现的脂肽类化合物，具有酶抑制活性和免疫抑制活性。它能抑制磷脂酶A2（PLA2）、PLC和PLD（IC50分别为2.9、1.3和1.4 µM）。Plipastatin A1（100 µg ml）能抑制LPS诱导的B细胞爆发生成和Concanavalin A诱导的T细胞爆发生成。在体内，Plipastatin A1（0.1 mg 动物）能抑制小鼠的迟发型超敏反应。

Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α±, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model.

Pd-C-II has anti-inflammation activity, it can inhibit TNF-α production and iNOS protein expression and inhibit COX-2 protein expression in LPS-stimulated RAW 264.7 cells. Pd-C-II inhibits anaphylactic mediator release from purified mast cells induced by

Concanamycin C, a natural macrolide antibiotic, was initially isolated from Streptomyces and identified as an inhibitor of T-cell proliferation in response to concanavalin A (1,2). It exhibits cytotoxicity to fungi, including yeasts, by inhibiting vacuolar-type ATPases (3,4).

Concanavalin A-AF594 (Con A-AF594) 可作为生命科学研究中使用的生物材料或有机化合物。