cholesterol esters

Pitavastatin calcium (NK-104) 是一种羟甲基戊二酰-CoA 还原酶抑制剂。它在 HepG2 细胞中抑制乙酸合成胆固醇的IC50为 5.8 nM。它是高效的肝细胞低密度脂蛋白胆固醇受体诱导剂。具有抗癌活性。

Cholesteryl behenate is a standard in electrospray ionization tandem mass spectrometry for the analysis of cholesteryl esters and cholesterol.

YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂，IC50为0.18 μM。

Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM.

Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 μM. It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 μM.

Cholesteryl heptadecanoate is a cholesterol ester (CE) formed by the condensation of cholesterol with heptadecanoic acid, a C-17 saturated fatty acid that does not occur in any natural animal or vegetable fat at high concentrations. As such, it is commonly used as an internal standard for the quantification of cholesterol esters by GC- or LC-mass spectrometry. CEs are major constituents of lipoprotein particles carried in blood and accumulate in the fatty acid lesions of atherosclerotic plaques. CEs of various fatty acids are major constituents of murine and human adrenal glands.

Cholesteryl erucate, a cholesterol ester, serves as a standard for the quantification of cholesterol esters in human meibomian gland secretions.

Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。

Pentacosanoic acid 是戊酸的共轭酸，是 25 碳长链饱和脂肪酸。

Cholesteryl palmitoleate, a cholesterol ester, exhibits elevated plasma levels in ApoE- - mice following exposure to cigarette smoke and in pediatric patients diagnosed with biliary atresia. It serves as a standard for identifying cholesterol esters in human meibomian gland secretions.

Cholesteryl 11,14-eicosadienoate, a cholesterol ester, serves as a synthetic intermediate in the production of cholesterol (methyl) esters.

Helminthosporol 是一种天然植物生长调节剂，能促进水稻和生菜幼苗的生长。此外，Helminthosporol 可抑制大鼠肝微粒体酰基辅酶 A：胆固醇酰基转移酶 (ACAT) 活性，并减少巨噬细胞中胆固醇酯的合成。

Cholesteryl n-butyrate 是胆固醇和丁酸形成的胆固醇酯。Cholesteryl n-butyrate 可用于合成具有抑制结肠癌细胞粘附及迁移活性的固体脂质纳米颗粒(SLN)，为抗癌药物丁酸酯提供递送系统。

Cholesterolhexanoate 是一种酯类有机化合物，由胆固醇与己酸反应生成。它在制药行业中有多种用途，特别是作为生物活性化合物，具有研究潜力，可用于改善高胆固醇和炎症相关疾病。该化合物也可能用作食品添加剂，以增强质地和稳定性。