chlorthalidone

Chlorthalidone 是噻嗪类利尿剂，有用于高血压的研究潜力。

Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM), which may mediate its sustained vasodilatory activity. Dietary administration of chlorthalidone (8 mg per animal per day) reduces arterial hypertension and prevents or reduces ventricular hypertrophy induced by deoxycorticosterone acetate (DOCA) in salt-hypertensive rats. Formulations containing chlorthalidone have been used alone or in combination with other antihypertensive agents to lower arterial blood pressure and as adjuvants to address edema caused by cardiac or renal disorders.

Chlorthalidoneimpurity，作为Chlorthalidone的代谢物，该物质属于噻嗪类利尿剂，主要用于高血压的研究。

Chlorthalidone-d4 是 Chlorthalidone 的氘代化合物。Chlorthalidone 的 CAS 号为 77-36-1。Chlorthalidone 是噻嗪类利尿剂，有用于高血压的研究潜力。