cell-surface protein

TAPI1 (TAPI) 是一种 ADAM17 TACE 抑制剂，可抑制细胞因子受体的脱落。

Elexacaftor (VX-445) 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。它促进CFTR 的加工和转运，增加细胞表面CFTR 的数量,改善 Phe508del CFTR 蛋白加工和运输。

OSMI-1 是一种 O-GlcNAc 转移酶 (OGT) 抑制剂 (IC50=2.7 μM)，具有口服活性和细胞渗透性。OSMI-1 可以抑制蛋白质 O-GlcNA 酰化，而不会定性地改变细胞表面 N- 或 O- 连接的聚糖。

Glutathione arsenoxide hydrochloride (Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)) 是一种潜在的抗癌活性分子和肿瘤代谢抑制剂。Glutathione arsenoxide hydrochloride 靶向线粒体内膜腺嘌呤核苷酸转移酶 (ANT)，对细胞增殖有抑制作用，促进细胞凋亡。Glutathione arsenoxide hydrochloride 可用于识别如蛋白质二硫异构酶一样的细胞表面蛋白质。

P53R3是一种有效的 p53再激活剂。P53R3可恢复 p53热点突变体的序列特异性 DNA 结合，包括p53 R175H、p53 R248W 和p53 R273H。P53R3特异性诱导p53依赖性抗增殖作用，其特异性比PRIMA-1高得多的。P53R3增强野生型p53和p53 M237I 向靶基因启动子的募集。P53R3强烈增强死亡受体死亡受体5（DR5）的mRNA、总蛋白和细胞表面的水平。P53R3用于癌症研究。

(S,S)-TAPI-1 是一种 TAPI-1 的异构体。其中 TAPI-1是金属蛋白酶 (MMP) 抑制剂，也是 TACE(ADAM17) 抑制剂，对多种细胞表面蛋白脱落表现出有效的抑制作用。

Sulfo-NHS-Biotin (Biotin-NHS) 是一种水溶性生物素化试剂，用于生物素-链霉亲和素结合反应。 Sulfo-NHS-Biotin (Biotin-NHS) 特别适用于在链霉亲和素-生物素测定中靶向细胞表面蛋白。与链霉亲和素和固定化链霉亲和素一起使用时，可用于蛋白质检测或固定。

Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物，是AMPKα的激活剂，具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。

Glycoprotein B is a peptide with the sequence H2N-Ser-Ser-Ile-Glu-Phe-Ala-Arg-Leu-OH, MW= 922.04. glycoprotein B is a viral glycoprotein that is involved in the viral cell entry of Herpes simplex virus. The herpesvirus glycoprotein B is the most highly c

Manninotrionate 是一种抗肿瘤化合物。将Manninotrionate 与BSA 偶联，并在兔体内制备了这种化合物-蛋白质偶联物的抗血清。该抗血清不凝集 Ehrlich 腹水肿瘤细胞，该细胞已被证明含有具有α-D-半乳糖基端基的细胞表面糖蛋白。

BS2G crosslinker (Bis[Sulfosuccinimidyl] glutarate) is an amine reactive, water-soluble, isofunctional protein crosslinker. The molecule is impenetrable to cell membranes and can be used to label cell surface proteins.

Pulchellin is a type-2 Ribosome Inactivating Protein (RIP), whose action mechanism proposed would be initiate by B-chain binding on glycoconjugate onto the cell surface (lectinic chain). pulchellin isoforms toxicity is the interaction between B-chain lect

Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)

CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50= 15 nM in a homologous time-resolved fret (HTRF) assay).1It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50= 6.6 μM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4+and CD8+T cells co-cultured with aAPCs. 1.Konieczny, M., Musielak, B., Kocik, J., et al.Di-bromo-based small-molecule inhibitors of the PD-1/PD-L1 immune checkpointJ. Med. Chem.63(19)11271-11285(2020)

Vanin-1-IN-2 是vanin-1的有效抑制剂(IC 50 = 162 nM)。Vanin-1 是在肾脏、肝脏和小肠中高水平表达的细胞表面相关的糖基磷脂酰肌醇 (GPI) 锚定蛋白。

GRP78-IN-2 是葡萄糖调节蛋白 78 (GRP78) 抑制剂，能够优先靶向细胞表面 GRP78，具有显著的的抗血管生成和抗癌作用，且不影响其他正常细胞。

(Rac)-OSMI-1 是 OSMI-1 的外消旋体。其中 OSMI-1 是 O-GlcNAc 转移酶 (OGT) 抑制剂 (IC50: 2.7 μM)。OSMI-1 对哺乳动物细胞系中的蛋白 O-连接的 N-乙酰氨基葡萄糖 (O-GlcNAcylation) 具有抑制作用，且不会定性地改变细胞表面 N-或 O-连接的聚糖。

M-COPA is a golgi disruptor which inhibits cell surface expression of MET protein and the ADP-ribosylation factor 1 (Arf1) activation. M-COPA also inhibits angiogenesis through suppression of both VEGFR1 2 and nuclear factor-kappaB (NF-kappaB) signaling pathways.

Patidegip, laos known as Saridegib and IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.

COVID-19 Spike Protein mRNA 用于表达新型冠状病毒肺炎刺突蛋白，关键于 RNA 传递、翻译效率与细胞活力的检测。该蛋白定位于病毒膜表面，主导病毒与宿主细胞膜受体的结合及膜融合，促使 COVID-19 病毒入侵细胞。同时，它是宿主中和抗体作用的主要位点与疫苗开发的核心靶标。

COVID-19 Spike Protein mRNA-LNP 是一种RNA传递系统，利用脂质纳米粒(LNP)封装COVID-19 Spike Protein mRNA，提高翻译效率与细胞活性。COVID-19 Spike Protein，位于新冠病毒膜表面，负责与宿主细胞受体结合和膜融合，是病毒进入细胞的关键因素，同时也是疫苗设计与宿主中和抗体生成的核心靶点。

Rabies VirusMatrix ProteinFragment (RV-MAT)为多肽类化合物，靶向细胞表面乙酰胆碱受体(AChR)。

Ac4GalNAlk是一个用于代谢寡糖工程(MOE)的试剂，带有弱炔标记，用于蛋白质糖基化的探测。通过细胞的生物合成机制，此MOE试剂可被激活成核苷酸糖，进而在生物正交化学中实现糖蛋白的引入，以便于进一步的追踪。Ac4GalNAlk有助于促进核苷酸-糖的生物合成，从而增强生物正交化学中细胞表面的标记。