cdk7 in 5

CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).

Roniciclib (BAY 1000394) 是一种有效的泛 CDK 抑制剂和新型口服细胞毒剂，对 CDK1、CDK2、CDK3、CDK4、CDK7 和 CDK9 的 IC50值为 5-25 nM。

CDK7-IN-28 (CDK7-1276) 是一种高效的CDK7抑制剂 (IC50<5 nM)，通过阻滞细胞周期和抑制 DNA 复制，实现对 MDA-MB-468 细胞系的抗增殖效果。

CDK7-IN-1 is an analog derived from YKL-5-124 and functions as an inhibitor of cyclin-dependent kinase 7 (cdk7). It exhibits strong inhibitory activity, with an IC50 value of less than 100 nM (WO 2016105528 A2, Compound 215).