A 65281 is an antibacterial isothiazoloquinolone and a potent inhibitor of the P4-unknotting reaction. It induces considerable DNA breakage mediated by calfthymus topoisomerase II.
A 65282 is an antibacterial isothiazoloquinolone and a potent inhibitor of the P4-unknotting reaction. It induces considerable DNA breakage mediated by calfthymus topoisomerase II.
HMCEF is a P-selectin inhibitor that acts by intercalating into calfthymusDNA, cutting off DNA pBR22. It also inhibits the proliferation of cancer cells.