bc-1485

BC-1485 是一种小分子 FIEL1（纤维化诱导E3连接酶1）抑制剂，可抑制 PIAS4 的降解，改善小鼠模型中的纤维化。

WS-691 is a highly Potent and Orally Active ABCB1 Modulator. WS-691 significantly increased sensitization of ABCB1-overexpressed SW620 Ad300 cells to paclitaxel (PTX) (IC50 = 22.02 nM). WS-691 significantly increased the intracellular concentration of PTX and [3H]-PTX while decreasing the efflux of [3H]- PTX in SW620 Ad300 cells by inhibiting the efflux function of ABCB1. WS-691 could stabilize ABCB1 by directly binding to ABCB1 WS-691 increased the sensitivity of SW620 Ad300 cells to PTX in vivo without observed toxicity.