AvanafilmetaboliteM16 is a major inactive metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafilmetaboliteM16 and avanafilmetabolite M4 , as well as minor metabolites.
Avanafilmetabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafilmetabolite M4 and avanafilmetaboliteM16 , as well as minor metabolites. Avanafilmetabolite M4 inhibits PDE5 with 18% of the potency of avanafil.