ard 61

ARD-61 is a potent and specific PROTAC androgen receptor (AR) degrader, exhibiting high effectiveness. It effectively induces the degradation of AR and progesterone receptors (PR) in AR+ cancer cell lines, leading to apoptosis. Additionally, ARD-61 demonstrates significant tumor growth inhibition in the MDA-MB-453 xenograft model in mice.

Boc-bipiperidine-ethynylbenzoic acid is an alkyl/ether-based PROTAC linker commonly employed for the synthesis of ARD-61.

PROTAC PTK6 ligand-1 是一种功能性中间体，用于 BTK 激酶抑制剂的制备，同时也是蛋白水解靶向嵌合体（PROTAC）开发中的关键合成构件，包括 ARD-61 的合成。PROTAC PTK6 ligand-1 被用于靶向蛋白降解研究，并促进以激酶驱动疾病模型为核心的先进药物化学研究。