ard 61

ARD-61 is a potent and specific PROTAC androgen receptor (AR) degrader, exhibiting high effectiveness. It effectively induces the degradation of AR and progesterone receptors (PR) in AR+ cancer cell lines, leading to apoptosis. Additionally, ARD-61 demonstrates significant tumor growth inhibition in the MDA-MB-453 xenograft model in mice.

PROTACPTK6 ligand-1是用于合成BTK激酶抑制剂的中间体，也可作为ARD-61合成的原料。

Boc-bipiperidine-ethynylbenzoic acid is an alkyl ether-based PROTAC linker commonly employed for the synthesis of ARD-61.