aq4

AQ4 是一种拓扑异构酶 II 抑制剂和 DNA 插入剂，在 CRC 细胞系中显示出抗肿瘤活性。AQ4 抑制两种细胞系的增殖并诱导细胞凋亡，同时降低 S6 的磷酸化。

Banoxantrone dihydrochloride (AQ4N dihydrochloride) 是一种新型缺氧细胞毒素，通过 iNOS 依赖机制选择性地杀死缺氧细胞。

Banoxantrone-D12 is the deuterium-labeled form of Banoxantrone,a bioreductive agent that can be metabolically converted to AQ4,a stable compound with DNA affinity and topoisomerase II inhibition properties.

Banoxantrone-D12 dihydrochloride is the deuterium-labeled Banoxantrone. Banoxantrone is a bioreductive agent that can be reduced to a stable,DNA-affinity compound AQ4,which is a topoisomerase II inhibitor.

Banoxantrone (AQ4N) 作为一种典型的缺氧选择性细胞毒素。Banoxantrone 可被还原为 AQ4，AQ4 是一种有效的拓扑异构酶 II 抑制剂。Banoxantrone 通过iNOS 依赖机制选择性地杀死缺氧细胞。Banoxantrone 显示出强大的细胞毒性和低氧选择性效应，且能被辐射增强。

Nemiralisib succinate is a potent and selective PI3Kδ inhibitor.