aq4

AQ4 是一种拓扑异构酶 II 抑制剂和 DNA 插入剂，在 CRC 细胞系中显示出抗肿瘤活性。AQ4 抑制两种细胞系的增殖并诱导细胞凋亡，同时降低 S6 的磷酸化。

Banoxantrone dihydrochloride (AQ4N dihydrochloride) 是一种新型缺氧细胞毒素，通过 iNOS 依赖机制选择性地杀死缺氧细胞。

Banoxantrone (AQ4N) 作为一种典型的缺氧选择性细胞毒素。Banoxantrone 可被还原为 AQ4，AQ4 是一种有效的拓扑异构酶 II 抑制剂。Banoxantrone 通过iNOS 依赖机制选择性地杀死缺氧细胞。Banoxantrone 显示出强大的细胞毒性和低氧选择性效应，且能被辐射增强。

Nemiralisib succinate is a potent and selective PI3Kδ inhibitor.

Banoxantrone D12 (AQ4N D12) is the deuterium-labeled form of Banoxantrone, a bioreductive agent that can be metabolically converted to AQ4, a stable compound with DNA affinity and topoisomerase II inhibition properties.

Banoxantrone D12 (AQ4N D12) dihydrochloride is the deuterium-labeled Banoxantrone. Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase II inhibitor.