apaziquone

Apaziquone has potential antineoplastic and radiosensitization activities. It is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA

Apaziquone (EOquin, EO9) 是一种吲哚喹诺酮类化合物，作为生物还原型前药，与较早的化疗化合物丝裂霉素C具有化学类似性。