an 11251

AN11251, a potent oral-active anti-Wolbachia agent, shows promise for treating onchocerciasis and lymphatic filariasis. Demonstrating EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6 36 cell lines, it exhibits significant efficacy across different laboratory settings.

Sitaxsentan (TBC-11251) 是选择性内皮素A (ETA) 受体拮抗剂。内皮素是一种有效的血管收缩剂。Sitaxsentan 阻断内皮素与其受体的结合，从而消除内皮素的有害作用。