aloisine a

Aloisine A is a potent and selective CDK GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1 cyclin B (IC50: 150nM), Cdk2 cyclin A (IC50: 120nM), Cdk2 cyclin E (IC50: 400nM), Cdk5 p25 (IC50: 200nM), Cdk5 p35 (IC50: 160nM), GSK-3α (IC50: 500nM), GSK-3β (IC50: 6

Aloisine B (AloisineB) 以 IC50 值分别为 0.85 µM 和 0.75 µM 抑制细胞周期依赖性激酶和糖原合成酶激酶。Aloisine B 具有抗病毒活性，可用于研究阿尔茨海默氏病、糖尿病、HIV 和帕金森病。