ahpc-peg2-acid

(S,R,S)-AHPC-PEG2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PROTAC YAP degrader-1 是一种专门靶向YAP并抑制其核内定位的PROTAC化合物。该化合物由PROTAC靶蛋白配体NSC682769和E3泛素连接酶配体+Linker的偶联体(R,S,R)-AHPC-PEG2-C2-boc构成，使用的PROTAC Linker为Acid-PEG2-C2-Boc，而其靶蛋白配体活性对照为Demethyl-NSC682769。