VEGFR-2-IN-10

VEGFR-2-IN-10 对 VEGF 诱导的VEGFR2磷酸化表现出增强的抗血管生成效力，IC50值为 0.7 μM，而无细胞毒性作用。

VEGFR-2-IN-63 (Compound 12b) 为VEGFR2抑制剂，在10 μM时可抑制87.2%的VEGFR-2活性。该化合物对多种癌细胞展现抗增殖效应，其对HCT116、MCF7和PaCa2的IC50值分别为6.5 μM、2.1 μM和4.1 μM。

The Immuno-Oncology Screening Library consists of 2 plates and contains more than 90 cancer and immunology-associated compounds in a 96-well Matrix tube rack format as 10 mM stock solutions in DMSO. This library includes a variety of immuno-oncology target modulators, including but not limited to, adenosine, CCR, CXCR, and TLR agonists and antagonists, BTK, PI3K, VEGFR, and BRAF inhibitors, PD-1/PDL-1 interaction inhibitors, and HDAC inhibitors. Please review the product insert for a full list of targets. Stability data is not available for the compounds as supplied in the screening library.