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25

抑制剂 & 化合物

19

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T39915	Trx-red Trx-red,NBL-SS perchlorate
	Trx-red (NBL-SS perchlorate) is a red-emitting fluorescent probe derived from the nile blue fluorophore. It is specifically designed for imaging thioredoxin (Trx) in live cells and in vivo, with excitation and emission wavelengths of 615 nm and 661 nm, respectively.
T7003	Leucomethylene blue mesylate N3,N3,N7,N7-四甲基-10H-吩噻嗪-3,7-二胺二甲磺酸盐,TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate	Beta Amyloid; Microtubule Associated	Cytoskeletal Signaling; Neuroscience
	Leucomethylene blue mesylate (TRx0237 mesylate) 是一种 Methylene blue (亚甲基蓝)的还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。它是一种具有口服活性的二代 tau 蛋白聚集的抑制剂 (Ki=为0.12 μM)，可用于阿尔兹海默症的研究。
T39586	Cantrixil TRX-E-002-1
	Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells. Cantrixil exhibits potent pan anti-cancer activity against various cancer phenotypes.
T30849	CGP-59326 UNII-YP9UZR062O,CGP59326,CGP 59326,TRX-13
	CGP-59326 is an epidermal growth factor receptor (EGFR) antagonist, which is used in anti-cancer research.
T3389	Antitumor agent-21 TRX818	Others	Others
	Antitumor agent-21 (TRX818) 是一种具有潜在的抗癌、抗炎、抗增殖、抗激素作用和抑制血管生成拟态作用的芳基-喹啉衍生物。
T13230	TXNIP-IN-1	Others	Others
	TXNIP-IN-1 是硫氧还蛋白-硫氧还蛋白相互作用蛋白复合物抑制剂。它在 TXNIP-TRX 复合物相关代谢紊乱的糖尿病、心血管疾病或炎症疾病方面有研究的价值。
T68257	Hydromethylthionine HBr
	Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacological activity on brain structure and function as both monotherapy and as an add-on to symptomatic treatment in certain patients with Alzheimer’s disease.
T7714	Temocapil	Tyrosinase	Proteases/Proteasome
	Temocapil 是一种酪氨酸激酶抑制剂。
T6698	Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利	RAAS	Endocrinology/Hormones
	Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。
T14835	BTRX-335140 CYM-53093	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BTRX-335140 (CYM-53093) 是一种有效的选择性口服活性 κ 阿片受体 (KOR) 拮抗剂，对 κOR、μOR 和 δOR 具有拮抗活性，IC50 值分别为 0.8、110 和 6500 nM。它可以很好地分布到 CNS 中，在大鼠中具有良好的体外吸收、分布、代谢、排泄和毒性以及体内药代动力学特征。
T29017	TrxR1-IN-B19 TrxR1INB19,Go Y015,TrxR1 IN B19,Go-Y015	Others	Others
	TrxR1-IN-B19 (TrxR1 IN B19) 是一种 TrxR1 抑制剂，通过靶向 TrxR1 和 ROS 介导的 ER 应激激活，通过小分子选择性杀死胃癌细胞。
T60453	TrxR-IN-3
	TrxR-IN-3 (Compound 2c) 是TrxR 的有效抑制剂。TrxR-IN-3 对五种人类癌细胞系表现出强大的抗增殖活性，特别是对乳腺肿瘤细胞。TrxR-IN-3 增加 ROS 水平并通过调节乳腺癌细胞中细胞凋亡相关蛋白的表达导致明显的细胞凋亡。TrxR-IN-3 还通过促进 LC3-II 和 Beclin-1 的表达并减少 LC3-I 和 p62 蛋白的表达，来触发自噬体和自溶酶体的形成。
T62021	TrxR-IN-2
	TrxR-IN-2 是潜在的硫氧还蛋白还原酶（TrxR）抑制剂。TrxR-IN-2在治疗耐药性肝细胞癌中有研究价值。
T29018	TrxR inhibitor D9 D9,TrxR-IN-D9
	TrxR-IN-D9 is a novel inhibitor of thioredoxin reductase (TrxR).
T73254	TrxR-IN-4
	TrxR-IN-4 (Compound 1b) 是一种针对 TrxR 的有效抑制剂，能够通过激活 ERS 诱导 HepG2 细胞的凋亡。此外，TrxR-IN-4 通过下调 TrxR 表达量和降低炎症水平，有效改善了 CCl4 诱导的肝损伤。
T61647	TrxR-IN-5
	TrxR-IN-5 (compound 4f) is an efficacious inhibitor of TrxR (thioredoxin reductase) with an IC50 of 0.16 μM. By elevating the levels of reactive oxygen species (ROS), TrxR-IN-5 fosters robust antiproliferative impacts. Additionally, TrxR-IN-5 demonstrates pronounced effects against cancer proliferation and metastasis [1].
T78781	TrxR1-IN-1
	TrxR1-IN-1 (Compound 5j) 是一种具有针对性的TrxR1抑制剂，显示出IC50值为8.8 μM的抑制效能。该化合物在治疗癌症方面表现出潜在效果，其对多种癌细胞系的IC50值分别为：MCF-7细胞系1.5 μM、HeLa细胞系1.7 μM、BGC-823细胞系2.4 μM、SW-480细胞系2.8 μM和 A549细胞系2.1 μM。此外，TrxR1-IN-1还表现出了抗氧化特性，能有效清除DPPH自由基。
T73992	IONIS-MAPTRx
	IONIS-MAPTRx (BIIB080) 是一个降低 Tau 的反义寡核苷酸 (ASO)。IONIS-MAPTRx 具有研究阿尔茨海默病的潜力。( MCE IONIS-MAPTRx 用于小鼠: TauASO-12序列 – 5′ GCTTTTACTGACCATGCGAG 3′ )
T2283	PX-12 2-[(1-甲基丙基)二硫代]-1H-咪唑,IV-2,PX12	Thioredoxin	Metabolism
	PX-12 (PX12) 是一种可逆的硫氧还蛋白-1(Trx-1)抑制剂，能够抑制 MCF-7 细胞(IC50:1.9 μM)和HT-29 细胞(IC50:2.9 μM)的生长。
TP1604L	Thioredoxin reductase peptide acetate Thioredoxin reductase peptide acetate(950890-23-0 free base)	Others	Others
	Thioredoxin reductase peptide acetate(950890-23-0 free base) 对应于硫氧还蛋白还原酶 (TrxR) 中的 53–67 位残基，用于硫氧还蛋白还原酶研究。哺乳动物硫氧还蛋白还原酶 (TR) 催化硫氧还蛋白 (Trx) 的氧化还原活性二硫键的还原，并且在结构和谷胱甘肽还原酶的作用机制，除了 C 末端的 16 个氨基酸延伸部分含有一个罕见的连位硒硫键。
T23166	PMX 464	Others	Others
	inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system
T28906	T6603185 T-6603185,T 6603185
	T6603185 is a novel inhibitor of peroxiredoxin (Prx) and thioredoxin (Trx) systems.
T83871	Ferroptocide
	Ferroptocide是一种抑制剂，可抑制硫氧还蛋白(Trx)活性，并且是pleuromutilin的衍生物。在20 µM的浓度下，Ferroptocide能够抑制ES-2卵巢癌细胞中的Trx活性，并对ES-2细胞具有细胞毒性(IC50 = 1.6 µM)。5 µM的Ferroptocide能够诱导ES-2细胞发生铁死亡，这一效应可以通过铁螯合剂去铁胺(DFO)、抗氧化剂Trolox或铁死亡抑制剂ferrostatin-1来阻断。在使用免疫完整但非免疫缺陷小鼠的4T1小鼠乳腺癌模型中，每周两次以50 mg/kg剂量给药时，Ferroptocide能够减少肿瘤体积。
T15062	DBCO-NHCO-PEG4-amine	Others	Others
	DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].
TP1604	Thioredoxin reductase peptide
	Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active disulfide bond of thioredoxin (Trx) and is

化合物

Cat.No: T39915

Synonym: Trx-red,NBL-SS perchlorate

Leucomethylene blue mesylate

Cat.No: T7003

Synonym: N3,N3,N7,N7-四甲基-10H-吩噻嗪-3,7-二胺二甲磺酸盐,TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate

Target: Beta Amyloid, Microtubule Associated

Cat.No: T39586

Synonym: TRX-E-002-1

Cat.No: T30849

Synonym: UNII-YP9UZR062O,CGP59326,CGP 59326,TRX-13

Antitumor agent-21

Cat.No: T3389

Synonym: TRX818

Target: Others

Cat.No: T13230

Target: Others

Hydromethylthionine HBr

Cat.No: T68257

Cat.No: T7714

Target: Tyrosinase

Temocapril hydrochloride

Cat.No: T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利

Target: RAAS

Cat.No: T14835

Synonym: CYM-53093

Target: Opioid Receptor

Cat.No: T29017

Synonym: TrxR1INB19,Go Y015,TrxR1 IN B19,Go-Y015

Target: Others

Cat.No: T60453

Cat.No: T62021

TrxR inhibitor D9

Cat.No: T29018

Synonym: D9,TrxR-IN-D9

Cat.No: T73254

Cat.No: T61647

Cat.No: T78781

Cat.No: T73992

Cat.No: T2283

Synonym: 2-[(1-甲基丙基)二硫代]-1H-咪唑,IV-2,PX12

Target: Thioredoxin

Thioredoxin reductase peptide acetate

Cat.No: TP1604L

Synonym: Thioredoxin reductase peptide acetate(950890-23-0 free base)

Target: Others

Cat.No: T23166

Target: Others

Cat.No: T28906

Synonym: T-6603185,T 6603185

Cat.No: T83871

DBCO-NHCO-PEG4-amine

Cat.No: T15062

Target: Others

Thioredoxin reductase peptide

Cat.No: TP1604

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02250	Thioredoxin/TRX Protein, Human, Recombinant thioredoxin,TRDX,DKFZp686B1993,MGC61975,TXN,TRX1,RP...	Human	E. coli
	Thioredoxin/TRX Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.7 kDa and the accession number is P10599.
TMPY-00382	Thioredoxin/TRX Protein, Mouse, Recombinant Txn,Txn1,thioredoxin	Mouse	E. coli
	Thioredoxin/TRX Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.7 kDa and the accession number is P10639.
TMPY-02084	Thioredoxin 2/TRX2 Protein, Human, Recombinant (His) MT-TRX,RP5-1119A7. 13-005,TRX2,MTRX	Human	E. coli
	Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small ...
TMPH-02781	Merlin Protein, Mouse, Recombinant (His & Trx)	Mouse	E. coli
	Merlin Protein, Mouse, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-Trx tag. The predicted molecular weight is 55.9 kDa and the accession number is P46662.
TMPJ-00826	TXN Protein, Human, Recombinant (His) ADF,TXN,TRX1,Thioredoxin,TRX,ATL-Derived F...	Human	E. coli
	Thioredoxin (TXN) is a member of the Thioredoxin family. Thioredoxin exists as a disulfide-linked homodimer and contains one Thioredoxin domain. Thioredoxin is up-regulated by ionizing radiation. Thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin also plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contri...
TMPJ-00971	PPIC Protein, Human, Recombinant (Trx & His) PPIase C,Peptidyl-Prolyl Cis-Trans Isomerase C,PPIC,Cyclophi...	Human	E. coli
	Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but prolines unusual structure stabilizes the cis form so...
TMPJ-00898	CD72 Protein, Human, Recombinant (Trx & His) Lyb-2,B-Cell Differentiation Antigen CD72,CD72	Human	E. coli
	B-Cell Differentiation Antigen CD72 (CD72) is a single-pass type II membrane protein. CD72 exists as a disulfide-linked homodimer and contains one C-type lectin domain. CD72 is expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells. CD72 is a ligand for CD5. CD72 associates with CD5, interacts with PTPN6/SHP-1 and plays a role in B-cell proliferation and differentiation. CD72 associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulat...
TMPJ-00361	Endoglin Protein, Human, Recombinant (Trx & His) CD105,END,Endoglin,ENG	Human	E. coli
	Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins an...
TMPJ-01145	ABCB5 Protein, Human, Recombinant (Trx) ABCB5 P-gp,ATP-binding cassette sub-family B member 5,ABCB5,...	Human	E. coli
	ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FL...
TMPH-01026	CAMK2N1 Protein, Human, Recombinant (His & Trx) Calcium/calmodulin-dependent protein kinase II inhibitor 1,C...	Human	E. coli
	Potent and specific inhibitor of CaM-kinase II (CAMK2). CAMK2N1 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-Trx tag. The predicted molecular weight is 25.6 kDa and the accession number is Q7Z7J9.
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx) SOCS-3,SSI-3,ATOD4,Cish3,SSI3,suppressor of cytokine signali...	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. ...
TMPH-01560	IL-26 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-T...
TMPY-05297	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx) LPG,apolipoprotein E,ApoE4,APO-E,LDLCQ5,AD2	Human	E. coli
	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with His and Trx tag. The predicted molecular weight is 51.3 kDa and the accession number is P02649.
TMPY-02430	BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx) BCL5,ZNF51,B-cell CLL/lymphoma 6,LAZ3,ZBTB27,BCL6A	Human	E. coli
	The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon...
TMPY-05528	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated APO-E,LDLCQ5,LPG,ApoE4,AD2,apolipoprotein E	Human	E. coli
	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated is expressed in E. coli expression system with His and Trx tag. The predicted molecular weight is 51.3 kDa and the accession number is P02649.
TMPY-05271	CD20 Protein, Human, Recombinant (TrxA), Biotinylated MS4A2,CD20,LEU-16,CVID5,membrane-spanning 4-domains, subfami...	Human	E. coli
	CD20 Protein, Human, Recombinant (TrxA), Biotinylated is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507.
TMPY-04615	CD20 Protein, Human, Recombinant (TrxA) MS4A2,CD20,CVID5,S7,Bp35,membrane-spanning 4-domains, subfam...	Human	E. coli
	CD20 Protein, Human, Recombinant (TrxA) is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507.
TMPY-02271	TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His) thioredoxin reductase 1,TR1,TXNR,TR,TRXR1,GRIM-12	Human	E. coli
	Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor th...
TMPY-02572	TXNDC17 Protein, Human, Recombinant thioredoxin domain containing 17,TXNL5,TRP14	Human	E. coli
	Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein family that lacks activity with classical Trx1 substrates. TXNDC17 is a novel 14-kDa disulfide reductase of the TXN (thioredoxin) family. TXNDC17 is involved in the TNF (tumor necrosis factor) signaling pathway. Moreover, TXNDC17 plays an important role in Taxol resistance via enha...

重组蛋白

Thioredoxin/TRX Protein, Human, Recombinant

Cat.No: TMPY-02250

Species: Human

Expression System: E. coli

Thioredoxin/TRX Protein, Mouse, Recombinant

Cat.No: TMPY-00382

Species: Mouse

Expression System: E. coli

Thioredoxin 2/TRX2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02084

Species: Human

Expression System: E. coli

Merlin Protein, Mouse, Recombinant (His & Trx)

Cat.No: TMPH-02781

Species: Mouse

Expression System: E. coli

TXN Protein, Human, Recombinant (His)

Cat.No: TMPJ-00826

Species: Human

Expression System: E. coli

PPIC Protein, Human, Recombinant (Trx & His)

Cat.No: TMPJ-00971

Species: Human

Expression System: E. coli

CD72 Protein, Human, Recombinant (Trx & His)

Cat.No: TMPJ-00898

Species: Human

Expression System: E. coli

Endoglin Protein, Human, Recombinant (Trx & His)

Cat.No: TMPJ-00361

Species: Human

Expression System: E. coli

ABCB5 Protein, Human, Recombinant (Trx)

Cat.No: TMPJ-01145

Species: Human

Expression System: E. coli

CAMK2N1 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPH-01026

Species: Human

Expression System: E. coli

SOCS3 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPY-02194

Species: Human

Expression System: E. coli

IL-26 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPH-01560

Species: Human

Expression System: E. coli

Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPY-05297

Species: Human

Expression System: E. coli

BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx)

Cat.No: TMPY-02430

Species: Human

Expression System: E. coli

Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated

Cat.No: TMPY-05528

Species: Human

Expression System: E. coli

CD20 Protein, Human, Recombinant (TrxA), Biotinylated

Cat.No: TMPY-05271

Species: Human

Expression System: E. coli

CD20 Protein, Human, Recombinant (TrxA)

Cat.No: TMPY-04615

Species: Human

Expression System: E. coli

TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)

Cat.No: TMPY-02271

Species: Human

Expression System: E. coli

TXNDC17 Protein, Human, Recombinant

Cat.No: TMPY-02572

Species: Human

Expression System: E. coli

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