| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T39561 | Orexin 2 Receptor Agonist 2 | ||
| Orexin 2 Receptor Agonist 2 (ORA-2) is a specific agonist for the orexin 2 receptor, obtained from patent WO2017135306A1 (example 16). | |||
| T3177 |
Orexin 2 Receptor Agonist
OX2R |
OX Receptor | GPCR/G Protein; Neuroscience |
| Orexin 2 Receptor Agonist 是一种选择性有效的OX2R 激动剂， EC50为23 nM。 | |||
| T39229 | YNT-185 | OX Receptor | GPCR/G Protein; Neuroscience |
| YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models. | |||
| T39808 | Firazorexton | ||
| Firazorexton is a potent orexin type 2 receptor (OX2R) agonist (patent WO2019027058A1, example 395). | |||
| TP1975L |
[Ala11,D-Leu15]-Orexin B acetate
[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) |
OX Receptor | GPCR/G Protein; Neuroscience |
| [Ala11,D-Leu15]-Orexin B acetate 是一种特异性 orexin-2 受体 (OX2) 激动剂，EC50 为 0.13 nM，比 OX1 (52 nM) 特异性高 400 倍。 | |||
| T75921 | [Ala11,D-Leu15]-Orexin B(human) TFA | ||
| [Ala11,D-Leu15]-Orexin B(human) TFA 是一种有效的，选择性的orexin-2 receptor (OX2)的激动剂。[Ala11,D-Leu15]-Orexin B(human) TFA 对 OX2 (EC50=0.13 nM) 比对 OX1 (52 nM) 高出 400 倍的选择性。 | |||
| T75925 | Orexin B, rat, mouse TFA | ||
| Orexin B, rat, mouse (Rat orexin B) TFA 是一种内源性增食欲素受体 (Orexin receptor) 激动剂。Orexin B, rat, mouse TFA 结合并激活两个密切相关的孤儿 G 蛋白偶联受体 OX1-R 和 OX2-R。Orexin B, rat, mouse TFA 刺激食物摄入和能量消耗，并在睡眠-觉醒调节中发挥重要作用。 | |||
| T37112 | YNT-185 dihydrochloride | ||
| Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice. Nagahara et al (2015) Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 58 7931 ... | |||
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