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Cat. No. | Product Name | Target | Signaling Pathways |
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TN7093 |
N-Caffeoyltryptophan
trans-Caffeoyl-L-tryptophan,反式咖啡酰-L-色氨酸 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan) 是一种潜在的 Sirt 抑制剂,使用咖啡提取物进行筛选。 N-Caffeoyltryptophan 抑制 Sirt2 (IC50; 8.7 μM) 优于 Sirt1 (IC50; 34μM)。 | |||
T71479 | Kahweol oleate | ||
Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
T68642 | Kahweol palmitate | ||
Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
T71480 | Kahweol linoleate | ||
Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
T71478 |
Kahweol stearate
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Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
T68641 |
Kahweol Acetate
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Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
T83929 |
(+)-JQ1 maleimide
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(+)-JQ1 maleimide是一种探针,由一个与BRD4配体JQ1通过PEG2连接器相连的含有活性的maleimide组成。它可用于COFFEE方法(COvalent Functionalization Followed by E3 Electroporation),在该方法中,(+)-JQ1 maleimide与VHL共价连接后通过电穿孔导入活细胞。E3连接酶在细胞内与BRD4形成复合物,引导其降解。 | |||
T37476 |
Cyclo(L-Phe-L-Val)
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Cyclo(L-Phe-L-Val) is a metabolite of the sponge bacterium Pseudoalteromonas sp. NJ6-3-1 that can autoinduce production of antibacterial substances active against S. aureus when co-cultured at a low cell density. It induces neurite outgrowth and branching of chick cortical neurons in vitro when used at concentrations of 16 and 32 μM. It increases phosphorylation of the PI3K substrate Akt, and neurite outgrowth induced by cyclo(L-Phe-L-Val) can be blocked by the PI3K inhibitor LY294002 . Cyclo(L-... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T4024 |
Norharmane
2-Azacarbazole,2,9-Diazafluorene,β-Carboline,去甲哈尔满 |
DNA; Endogenous Metabolite; Monoamine Oxidase | DNA Damage/DNA Repair; Metabolism; Neuroscience |
Norharmane (β-Carboline) 是一种有效的选择性单胺氧化酶 A (MAO-A) 抑制剂,Ki=3.34 μM。 | |||
T37705 |
1,2,4-Trihydroxybenzene
Benzene-1,2,4-triol |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
1,2,4-Trihydroxybenzene (Benzene-1,2,4-triol) 是咖啡豆烘焙的副产品,是在小鼠、阿拉伯咖啡中发现的。1,2,4-Trihydroxybenzene 是一种苯三醇, 它能增加大鼠胸腺淋巴细胞内的Ca2+浓度。 | |||
T2927 |
Trigonelline chloride
Gynesine Hydrochloride,盐酸葫芦巴碱,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride |
Others; Antibacterial; Antifungal; HSV | Microbiology/Virology; Others |
Trigonelline chloride (Coffearine Hydrochloride) 是一种大量存在于咖啡中的生物碱,具有潜在抗糖尿病活性。它还具有抗HSV-1,抗菌和抗真菌活性。 | |||
T2887 |
Trigonelline
Trigenolline,葫芦巴碱 |
Apoptosis; Others; Ferroptosis; Endogenous Metabolite | Apoptosis; Metabolism; Others |
Trigonelline (Trigenolline) 是一种大量存在于咖啡中的生物碱,具有潜在抗糖尿病活性。它是Nrf2抑制剂,可阻断 Nrf2 依赖的蛋白酶体活性,从而增强胰腺癌细胞凋亡。 | |||
TCP2934 |
5-Methylfurfural
5-Methyl furfural,5-Methyl-2-furaldehyde,5-甲基呋喃醛 |
Others | Others |
5-Methylfurfural (5-Methyl-2-furaldehyde) 是一种天然存在的调味剂,存在于香烟烟雾凝结物,烤土豆粉,甘草精油,储存的脱水橙粉,挥发性化合物的烤牛肉,香气浓缩的海绵蛋糕,咖啡,面包,茶和可可种。 | |||
TN7073 |
3-Feruloyl-4-caffeoylquinic acid
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Others | Others |
3-Feruloyl-4-caffeoylquinic acid 是一种绿原酸异构体。绿原酸是相关的咖啡品质标志、味道和香气前体以及重要的生物活性化合物。 | |||
T3158 |
Harmane
Loturine,Harman,Aribine,哈尔满碱 |
Adrenergic Receptor; Monoamine Oxidase; Imidazoline Receptor | GPCR/G Protein; Neuroscience |
Harmane (Loturine) 是一种在咖啡和烟草烟雾中发现的 β-咔啉生物碱,是有效的神经毒素,可引起严重的动作震颤和精神病学表现。它还是选择性的单胺氧化酶抑制剂,具有致突变作用,对 MAO A/B 的 IC50值分别为 0.5 和 5 μM。 | |||
T3791 |
Atractyloside A
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AChR | Neuroscience |
Atractyloside A 是存在于一些植物中的贝壳杉类二萜糖苷,具有降血压、降血糖、抗肿瘤等活性。 | |||
T38248 |
2-Ethylpyrazine
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Endogenous Metabolite; NO Synthase | Immunology/Inflammation; Metabolism |
2-Ethylpyrazine 存在与烘焙后的咖啡豆中,是一种挥发性化合物 。2-Ethylpyrazine 通过内皮衍生的松弛因子的活动诱导血管舒张。2-Ethylpyrazine 通过内皮内皮NO 合酶的作用激活NO 合成。2-Ethylpyrazine 通过诱导NO 释放和增加外周血流量来诱导血管舒张。 | |||
T67302 |
2,3-Pentanedione
Acetylpropionyl |
Others | Others |
2,3-Pentanedione 是一种食品添加剂, 也作为发酵产物自然存在于啤酒、葡萄酒和酸奶中,并在咖啡豆烘焙过程中释放。吸入2,3-Pentanedione 被认为是人严重呼吸道疾病(包括闭塞性细支气管炎)的原因。 | |||
T83444 |
16-O-Methylcafestol
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16-O-Methylcafestol为咖啡醇衍生物,可自生咖啡豆中提取。 | |||
T20602 |
2-Acetyl-5-methylthiophene
Methylthienylcetone |
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2-Acetyl-5-methylthiophene is a component of coffee aroma. | |||
TN7031 |
4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
Caramel Furanone,Fenugreck Lactone,Sotolone,葫芦巴内酯 |
Others | Others |
4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one (Fenugreck Lactone) 是一种食品香料,主要用于焦糖、红糖、威士忌、棉花糖、咖啡、太妃糖等香精。 |