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Targets Recommended: FXR Autophagy

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Cat. No. Product Name Target Signaling Pathways
T7436 Cilofexor

FXR; Autophagy Autophagy; Metabolism
Cilofexor 是一种法尼醇 X 受体激动剂,EC50为 43 nM。它抑制合成肽的结合,具有抗炎和抗纤维化作用。它可用于原发性硬化性胆管炎和非酒精性脂肪性肝炎的研究。
T69724 Cilofexor tromethamine

Others Others
Cilofexor, also known as GS-9674, is a farnesoid X receptor (FXR) agonist. The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC. In clinical study, cilofexor was well tolerated and led to significant improvements in liver biochemistries and markers of cholestasis in patients with PSC.
T69723 Taminadenant mesylate

Others Others
Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell sur...

化合物

Cilofexor
Cat.No: T7436
Synonym:
Target: FXR, Autophagy
Cilofexor tromethamine
Cat.No: T69724
Synonym:
Target: Others
Taminadenant mesylate
Cat.No: T69723
Synonym:
Target: Others
TargetMol Loading
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