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Targets Recommended: Others Histone Methyltransferase

6

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T21767 MS37452

Others; Histone Methyltransferase Chromatin/Epigenetic; Others
MS37452 是 CBX7 chromodomain 与 H3K27me3 结合的竞争性抑制剂,Ki 为 43 µM。它通过置换 CBX7 与前列腺癌细胞中INK4A/ARF 基因座的结合,抑制多梳抑制复合物靶基因 p16/CDKN2A 的转录。
T4021 UNC3866

Histone Methyltransferase Chromatin/Epigenetic
UNC3866 CBX7-H3 相互作用的有效拮抗剂,IC50为 66±1.2 nM。
T4021L UNC3866 TFA(1872382-47-2 free base)

Histone Methyltransferase Chromatin/Epigenetic
UNC3866 TFA(1872382-47-2 free base) 是由 AlphaScreen 确定的 CBX7-H3 相互作用的有效拮抗剂。
T35561 MS351

MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain. It enhances the binding of long noncoding RNA to the CBX7 chromodomain when used at 25 μM. MS351 induces transcriptional derepression of CBX7 target genes, including p16 (INK4a), in mouse embryonic stem cells and human prostate cancer PC3 cells.
T73903 UNC4976 TFA

UNC4976 TFA为CBX7染色质结构域与核酸结合的PAM(正变构调节剂)拟肽。通过拮抗H3K27me3,特异性阻断CBX7对靶基因的募集,同时促进了与DNA和RNA的非特异性结合。
T13255 UNC4976

Others Others
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.

化合物

MS37452
Cat.No: T21767
Synonym:
Target: Others, Histone Methyltransferase
UNC3866
Cat.No: T4021
Synonym:
Target: Histone Methyltransferase
UNC3866 TFA(1872382-47-2 free base)
Cat.No: T4021L
Synonym:
Target: Histone Methyltransferase
MS351
Cat.No: T35561
Synonym:
Target:
UNC4976 TFA
Cat.No: T73903
Synonym:
Target:
UNC4976
Cat.No: T13255
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPH-01089 CBX7 Protein, Human, Recombinant (His)

Chromobox protein homolog 7,CBX7

Human E. coli
CBX7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.3 kDa and the accession number is O95931.

重组蛋白

CBX7 Protein, Human, Recombinant (His)
Cat.No: TMPH-01089
Species: Human
Expression System: E. coli
TargetMol Loading
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