420089-51-6

Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis. By doing so, it effectively induces rapid cell death in mycobacteria. Thiophene-2 demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.

TP-2 是一种菱角状多阳离子小分子，作为解毒剂能够完全中和普通肝素 (UFH) 和低分子肝素 (LMWH)。与鱼精蛋白相比，TP-2 具有更高的中和活性，并且生物相容性良好。