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抑制剂&激动剂
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TargetMol产品目录中 "α4β1 integrin"的结果
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TargetMol产品目录中 "

α4β1 integrin

"的结果
  • 抑制剂&激动剂
    28
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    1
    TargetMol | Recombinant_Protein
  • 多肽产品
    6
    TargetMol | Peptide_Products
  • 抗体抑制剂
    2
    TargetMol | Inhibitory_Antibodies
  • 天然产物
    1
    TargetMol | Natural_Products
  • RO0270608
    T36716220846-33-3In house
    RO0270608,是 R411 的活性代谢物,是一种具有口服活性的双重 α4β1 α4β7 整合素拮抗剂,具有抗炎活性,可调节炎症,可用于研究过敏性炎症反应。
    • ¥ 1290
    In stock
    规格
    数量
  • Firategrast
    非拉司特, SB 683699
    TQ0291402567-16-2In house
    Firategrast (SB 683699) 是一种具有口服活性和特异性的α4β1 α4β7整合素拮抗剂。Firategrast 减少淋巴细胞进入中枢神经系统 (CNS) 的运输,降低多发性硬化症 (MS) 的活性。Firategrast 用于复发缓解性多发性硬化症。Firategrast 治疗与中位脑脊液与 CD4,CD8和CD19淋巴细胞计数的适度降低有关。
    • ¥ 328
    In stock
    规格
    数量
  • Natalizumab
    那他珠单抗
    T12177189261-10-7
    Natalizumab 是重组人源化单克隆抗体,与 α4β1-整联蛋白结合并阻断其与血管细胞粘附分子 1 的相互作用。它也可阻止淋巴细胞进入中枢神经系统,从而防止急性脱髓鞘复发,可用于复发缓解型多发性硬化症和克罗恩氏病的研究。
    • ¥ 1320
    In stock
    规格
    数量
  • BIO-1211
    T21868187735-94-0
    BIO-1211 是高度选择性的、口服有效的α4β1 (VLA-4)抑制剂,对 α4β1 和 α4β7 的 IC50分别为 4 nM 和 2 μM。
    • ¥ 1160
    In stock
    规格
    数量
  • Valategrast hydrochloride
    Valategrast HCl, R411, RO0272441, RO27244, RO-27-2441, R-411, RO-0272441
    T29089828271-96-1
    Valategrast hydrochloride (R411) 是一种有效的整联蛋白 α4β1 (VLA-4) 和 α4β7 双重拮抗剂。Valategrast hydrochloride 可用于慢性阻塞性肺疾病 (COPD) 和哮喘的研究。
    • ¥ 11700
    6-8周
    规格
    数量
  • Carotegrast methyl
    AJM300
    T30751401905-67-7
    Carotegrast methyl (AJM300) 是一种口服有效和选择性 α4 整联蛋白拮抗剂,可预防小鼠结肠炎。HCA2969 是 Carotegrast methyl 的活性代谢产物,是一种特异的双重 α4β1 α4β7 整联蛋白拮抗剂。
    • ¥ 689
    In stock
    规格
    数量
  • TR-14035
    MDK-1191
    T5310232271-19-1
    TR-14035 (MDK-1191) 是一种具有口服活性的 α4β7 α4β1整合素双重抑制剂,对 α4β7和 α4β1作用的 IC50值分别为 7 和 87 nM,可用于炎症和自体免疫疾病的研究。
    • ¥ 407
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32)
    T9901A-503
    Anti-Mouse LPAM-1 Integrinα4β7 Antibody (DATK32) 是一种来源于大鼠的IgG2a, κ类型抗体,专用于抑制小鼠 LPAM-1 Integrinα4β7。
    • ¥ 1820
    2-4周
    规格
    数量
  • Valategrast
    R-411 free base
    T13277220847-86-9
    Valategrast is a potent and orally active dual antagonist of integrin α4β1 (VLA-4) and α4β7, with the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment.
    • ¥ 2120
    5日内发货
    规格
    数量
  • Zaurategrast ethyl ester sulfate
    UCB1184197 sulfate, CDP323 sulfate
    T133881214261-78-5
    Zaurategrast ethyl ester sulfate is a α4β1 α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.
    • ¥ 11700
    6-8周
    规格
    数量
  • Zaurategrast ethyl ester
    UCB1184197, CDP323
    T13388L455264-30-9
    Zaurategrast ethyl ester is the ethyl ester prodrug of CT7758 and is an α4β1 α4β7 integrin antagonist. It is used for the treatment of inflammatory and autoimmune disorders.
    • ¥ 2890
    5日内发货
    规格
    数量
  • RO0505376
    UHG8ON73DX, RO-0505376, RO 0505376, CHEMBL2332742
    T202390343981-29-3
    RO0505376是一种α4β1整合素拮抗剂。
    • 待询
    10-14周
    规格
    数量
  • LDV FITC
    T235681207610-07-8
    fluorescent ligand that binds to the α4β1 integrin (VLA-4)
    • 待估
    35日内发货
    规格
    数量
  • BIO-7662
    BIO7662
    T23795327613-10-5
    BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.
    • ¥ 12800
    8-10周
    规格
    数量
  • Integrin modulator 1
    T362912023788-32-9
    Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1]. Integrin modulator 1 (2-10 μg mL; 30 min) significantly increases Jurkat E6.1 cell adhesion[1].Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1 2 phosphorylation in Jurkat E6.1 cells[1].Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the binding of HUTS-21 antibody to Jurkat E6.1 cells in a concentration-dependent manner[1]. [1]. Baiula M, et, al. New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. J Med Chem. 2016 Nov 10;59(21):9721-9742.
    • ¥ 2480
    5日内发货
    规格
    数量
  • bio5192 hydrate
    T36296
    BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels[1][2]. The combination of BIO5192 hydrate (1 mg kg; i.v.) and Plerixafor (5 mg kg; s.c.) exert an additive effect on progenitor mobilization[1].BIO5192 hydrate (30 mg kg; s.c; bid; during days 5 through 14) delays paralysis associated with EAE (experimental autoimmune encephalomyelitis)[2].BIO5192 hydrate (1 mg kg, i.v.) shows the terminal half-life is 1.1 hours. BIO5192 hydrate (3, 10, and 30 mg kg; s.c.) shows half-lives of 1.7, 2.7, and 4.7 hours, respectively. The blood plasma curves show that the AUC for the s.c. route of administration increased about 2.5-fold from 5,460 h*ng ml for the 3 mg kg dose to 14,175 h*ng ml for the 30 mg kg[1]. Animal Model: C57BL 6J x 129Sv J F1 mice[1] [1]. Ramirez P, et al. BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood. 2009;114(7):1340‐1343. [2]. Leone DR, et al. An assessment of the mechanistic differences between two integrin alpha 4 beta 1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis. J Pharmacol Exp Ther. 2003;305(3):1150-1162.
    • 待询
    规格
    数量
  • Irigenin
    野鸢尾黄素
    T3862548-76-5
    Irigenin 可通过特异性和选择性地阻断 Extra Domain A 域的 C-C 环上α9β1和α4β1整合素结合位点,介导其抗转移作用。可通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡,具有抗癌作用。
    • ¥ 123
    In stock
    规格
    数量
  • THI0019
    THI0019
    T387931378532-99-0
    THI0019 is a highly potent agonist of the integrin α4β1 (VLA-4) receptor, with an EC 50 range of 1-2 μM. It effectively promotes the adhesion of stem progenitor cells. Furthermore, THI0019 successfully modulates adhesion processes mediated by α4β7, α5β1, and αLβ2 integrins.
    • ¥ 9880
    6-8周
    规格
    数量
  • BOP-JF549
    BOP-JF549
    T41149
    BOP-JF549 is a fluorescent dual α9β1 α4β1 integrin inhibitor. Comprises BOP conjugated to Janelia Fluor® 549. Fluorogenic: fluoresces only once bound to integrins, enabling hassle-free no-wash experiments. Bright and photostable, enabling live cell tracking of integrin receptors over long time-course experiments. Excitation maximum = 549 nm; emission maximum = 571 nm.
    • 待估
    35日内发货
    规格
    数量
  • BOP-JF646
    BOP-JF646
    T41153
    BOP-JF646 is a fluorescent dual α9β1/α4β1 integrin inhibitor. Comprises BOP conjugated to Janelia Fluor®646. Fluorogenic: fluoresces only once bound to integrins, enabling hassle-free no-wash experiments. Bright and photostable, enabling live cell tracking of integrin receptors over long time-course experiments. Excitation maximum = 655 nm; emission maximum = 672 nm.
    • 待估
    35日内发货
    规格
    数量
  • TBC-3486
    T69619247044-77-5
    TBC-3486 is a novel potent inhibitor of integrin α4, being 200-fold more potent in inhibiting α4β1 than α4β7.
    • ¥ 12800
    8-10周
    规格
    数量
  • ProMMP-9 inhibitor-3c
    T698752138321-18-1
    ProMMP-9 inhibitor-3c is a potent and specific proMMP-9 inhibitor which disrupts f MMP-9 homodimerization and prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR.
    • ¥ 10600
    6-8周
    规格
    数量
  • R-BC154 acetate
    T74072
    R-BC154 acetate为选择性的荧光α9β1整合素拮抗剂,其作为高亲和力、活化依赖的整合素探针,主要应用于研究促细胞生长因子α9β1和α4β1的结合活性。
    • 待询
    规格
    数量
  • REDV
    T76286107978-83-6
    REDV 是纤连蛋白交替剪接的 III 型连接段 (IIICS) 区域的 CS5 位点内的活性序列。REDV 可以通过结合整合素α4β1介导与血浆纤连 IIICS 区域的粘附。REDV 可用于细胞粘附的研究。
    • 待询
    规格
    数量