(r) thalidomide

(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 作为PROTAC(R)-NX-2127中的E3泛素连接酶配体和连接子，主要应用于癌症研究领域。

Thalidomide-PIP-(R)C-pyrrolidine-boc is a conjugate comprising an E3 ligase ligand and a linker, specifically containing Thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of the CRBN protein, and is a crucial intermediate in synthesizing complete PROTAC molecules.

Iberdomide (CC-220) 是一种口服有效的 cereblon E3 连接酶调节剂，对 cereblon 结合亲和力的 IC50约为150 nM。它是沙利度胺的衍生物，具有抗肿瘤和免疫刺激活性。

(R)-Thalidomide是一种COX 1 2的抑制剂，能够诱导MCF-7，IM-9，HS-Sultan，KB等癌细胞凋亡。

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide - linker 11 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide amide-alkylC8-amine PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Thalidomide 5'-amine-alkylC6-amine是用于PROTAC研究与开发的功能化cereblon配体；包含一个E3连接酶配体和一个带有末端胺基的alkylC6连接器，用于与目标蛋白配体的结合。这是一系列用于PROTAC研发的功能化工具分子之一。