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R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)

R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)

产品编号 TMPY-01147
别名: RSPO, CRISTIN3, R-spondin 1

R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is Q2MKA7-1.

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R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,930 现货
200 μg ¥ 6,940 5日内发货
500 μg ¥ 14,680 5日内发货
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产品目录号及名称: R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) (TMPY-01147)
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生物活性
技术参数
产品性质
参考文献
生物活性 1. Measured by its binding ability in a functional ELISA. Immobilized human RSPO1 at 20 μg/ml (100 μl/well) can bind human LIMPII with a linear range of 32-800 ng/ml. 2. Measured by its binding ability in a functional ELISA. Immobilized human RSPO1 at 20 μg/ml (100 μl/well) can bind mouse CD36 with a linear range of 6.4-800 ng/ml. 3. Measured by its ability to induce activation of ßcatenin response in a Topflash Luciferase assay using HEK293T human embryonic kidney cells. The ED50 for this effect is typically 0.1-0.9 μg/mL in the presence of 5 ng/mL recombinant mouse Wnt3a.

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产品描述 R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is Q2MKA7-1.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 Q2MKA7-1
别名 RSPO, CRISTIN3, R-spondin 1
蛋白构建 The Human RSPO1 (NP_001033722.1) (Met 1-Ala 263) was expressed fused with a polyhistidine tag at the C-terminus.
蛋白纯度 > 95 % as determined by SDS-PAGE

TargetMol

分子量 28.2 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.

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Keywords

R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) RSPO CRISTIN3 R-spondin 1 CRISTIN-3 CRISTIN 3 recombinant recombinant-proteins proteins protein

 

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