IL-23 P19/IL23A Protein, Human, Recombinant (hFc)

IL-23 P19/IL23A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9NPF7.

规格	价格/CNY		数量
50 μg	￥ 2,430	现货
100 μg	￥ 4,120	5日内发货
200 μg	￥ 6,970	5日内发货
500 μg	￥ 13,930	5日内发货

规格

价格/CNY

货期

数量

50 μg

￥ 2,430

现货

100 μg

￥ 4,120

5日内发货

200 μg

￥ 6,970

5日内发货

500 μg

￥ 13,930

5日内发货

生物活性	Testing in progress
产品描述	IL-23 P19/IL23A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9NPF7.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q9NPF7
别名	IL-23A, IL-23, interleukin 23, alpha subunit p19, SGRF, IL23P19, P19, interleukin 23, α subunit p19
蛋白构建	The Human IL23A (NP_057668.1) (Met1-Pro189) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE.
分子量	45.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy