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IL-21 Protein, Canine, Recombinant

产品编号 TMPY-02809

别名: interleukin 21, 白细胞介素, 白介素

IL-21 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is Q6L7I9.

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IL-21 Protein, Canine, Recombinant

规格	价格/CNY		货期	数量
20 μg	￥ 1,750		5日内发货
100 μg	￥ 4,920		5日内发货

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参考文献

生物活性	Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 0.4-2 ng/ml.
产品描述	IL-21 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is Q6L7I9.

种属	Canine
表达系统	E. coli
标签	Tag Free
蛋白编号	Q6L7I9
别名	interleukin 21, 白细胞介素, 白介素
蛋白构建	The canine IL21 (Q6L7I9) (His 18-Ser 146) was expressed, with an initial Met at the N-terminus.
蛋白纯度	> 97 % as determined by SDS-PAGE
分子量	15 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Kuchen S, et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179(9):5886-96. 2. Wei L, et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282(48):34605-10. 3. Parrish-Novak J, et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63. 4. Coquet JM, et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34.

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Keywords

IL-21 Protein, Canine, Recombinant interleukin 21 白细胞介素白介素 recombinant recombinant-proteins proteins protein

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