GPRC5D Protein, Human, Recombinant (His & FLAG), Detergent is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 32.83 kDa and the accession number is Q9NZD1.

Human

HEK293 Cells

GPRC5D

A DNA sequence encoding the human GPRC5D (Q9NZD1) (Met1-Ser268) was expressed, with a Flag tag at the N-terminus and a polyhistidine tag at the C-terminus. Predicted N terminal: Met

≥ 80 % as determined by SDS-PAGE.

It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 3 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is highly and selectively expressed on the surface of CD138+ multiple myeloma (MM) cells, whereas in normal tissues, a much lower expression is limited to plasma cells and certain hard keratinizing tissues. This makes GPRC5D a promising marker for monitoring tumor load and a target antigen for MM-specific T cell-engaging therapies such as bispecific antibodies and CAR-T cells.