CRIP2 Protein, Human, Recombinant

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产品编号 TMPY-03459

CRIP2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 22.6 kDa and the accession number is P52943.

CRIP2 Protein, Human, Recombinant

一键复制产品信息

产品编号 TMPY-03459

CRIP2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 22.6 kDa and the accession number is P52943.

规格	价格	库存
5 μg	¥ 683	6-8日内发货
10 μg	¥ 1,130	6-8日内发货
20 μg	¥ 1,930	5日内发货
50 μg	¥ 4,430	5日内发货

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产品信息

生物活性	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述	CRIP2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 22.6 kDa and the accession number is P52943.
种属	Human
表达系统	Baculovirus Insect Cells
标签	Tag Free
蛋白编号	P52943
别名	ESP1,cysteine-rich protein 2,CRP2,CRIP
蛋白构建	A DNA sequence encoding the human CRIP2 (P52943) (Met1-Pro208) was expressed and purified. Predicted N terminal: Gly
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	22.6 kDa (predicted); 26 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM Nacl, 10% glycerol, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-κB/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis.