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N-(4-methoxyphenyl)prop-2-enamide

Name: N-(4-methoxyphenyl)prop-2-enamide
Brand: TargetMol
SKU: T50041
Price: 235 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: N-(4-甲氧苯基)丙烯酰基酰胺, N-(4-Methoxyphenyl)acrylamide

货号 T50041Cas号 7766-37-2 一键复制产品信息纯度: 99.54%

很棒

N-(4-methoxyphenyl)prop-2-enamide (N-(4-Methoxyphenyl)acrylamide) 是一种用作分子结构单元的丙烯酰胺类化合物。它可以抑制乙酰胆碱酯酶，增加突触间隙中的乙酰胆碱水平；也可以抑制多巴胺的分解，导致大脑中多巴胺水平的升高。

N-(4-methoxyphenyl)prop-2-enamide

一键复制产品信息

很棒

纯度: 99.54%

货号 T50041Cas号 7766-37-2

别名 N-(4-甲氧苯基)丙烯酰基酰胺, N-(4-Methoxyphenyl)acrylamide

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 235	现货
5 mg	¥ 532	现货
10 mg	¥ 792	现货
25 mg	¥ 1,360	现货
50 mg	¥ 2,030	现货
100 mg	¥ 2,950	现货
200 mg	¥ 3,970	现货
1 mL x 10 mM (in DMSO)	¥ 385	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.54%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

N-(4-methoxyphenyl)prop-2-enamide AI Summary

N-(4-methoxyphenyl)prop-2-enamide inhibits human recombinant tissue transglutaminase 2 (TG2) with an IC50 value of 58000.0 nM as measured by a fluorescent transamidation assay. It has a half-life of 8.733 hours in phosphate buffer at pH 7.4 and a concentration of 50 µM in the presence of glutathione, as determined by LC-MS analysis. The compound displays bioactivity related to intrinsic clearance with a rate of 10.72 µL/min/(10^6 cells) in human hepatocytes and 42.66 µL/min/(10^6 cells) in rat hepatocytes. Additionally, it has a logD7.4 value of 1.68, indicating its distribution in an octan-1-ol/water system at pH 7.4. Furthermore, N-(4-methoxyphenyl)prop-2-enamide inhibits various enzymes and viruses, including West Nile virus NS2B-NS3 protease, Dengue virus serotype 2 NS2B-NS3 protease, and bovine thrombin, among others, with inhibition levels below 15.0%. It shows low reactivity with glutathione (GSH), forming adducts slowly, with an activity range from less than 0.1 L/mol/s up to less than 5.0% over various time frames. Its covalent reactive group exhibits a pseudo-first-order reaction rate constant (K) of 2.6 x 10^-3/min at 37°C, along with a reaction half-life with GSH of 4.5 hours at pH 7.4. Additionally, the compound shows thiol reactivity in PBS/DMSO buffer with a pseudo-first-order rate constant for adduct formation at K = 3.9 x 10^-5/s..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	N-(4-methoxyphenyl)prop-2-enamide (N-(4-Methoxyphenyl)acrylamide) is an acrylamide analog used as a molecular structural unit. It inhibits the enzyme acetylcholinesterase, increasing acetylcholine levels in the synaptic gap. It can also inhibit the breakdown of dopamine, leading to increased dopamine levels in the brain.
别名	N-(4-甲氧苯基)丙烯酰基酰胺, N-(4-Methoxyphenyl)acrylamide

化学信息

分子量	177.2
分子式	C₁₀H₁₁NO₂
CAS No.	7766-37-2
Smiles	COC1=CC=C(NC(=O)C=C)C=C1
密度	1.12g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 55 mg/mL (310.38 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6433 mL	28.2167 mL	56.4334 mL	282.1670 mL
5 mM	1.1287 mL	5.6433 mL	11.2867 mL	56.4334 mL
10 mM	0.5643 mL	2.8217 mL	5.6433 mL	28.2167 mL
20 mM	0.2822 mL	1.4108 mL	2.8217 mL	14.1084 mL
50 mM	0.1129 mL	0.5643 mL	1.1287 mL	5.6433 mL
100 mM	0.0564 mL	0.2822 mL	0.5643 mL	2.8217 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

N-(4-methoxyphenyl)prop-2-enamide N(4methoxyphenyl)prop2enamide N (4 methoxyphenyl)prop 2 enamide

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N-(4-methoxyphenyl)prop-2-enamide

N-(4-methoxyphenyl)prop-2-enamide

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词